Citations and Co-Authorships with Top Pharmaceutical Companies

For over two decades, CPC Scientific has advanced the research of leading pharmaceutical companies through our expertise in chemical synthesis and molecular design.

  • Novel Pan-Coronavirus 3CL Protease Inhibitor MK-7845: Biological and Pharmacological Profiling.

    Alvarez, N., Adam, G.C., Howe, J.A., Sharma, V., Zimmerman, M.D., Dolgov, E., Rasheed, R., Nizar, F., Sahay, K., Nelson, A.M. and Park, S. Viruses 16, no. 7 (2024): 1158.

    1. Center for Discovery and Innovation, Hackensack Meridian Health, 111 Ideation Way, Nutley, NJ 07110, USA
    2. Merck & Co., Inc., Rahway, NJ 07065, USA

    The enzymatic activity of recombinantly expressed 3CLPro enzymes from different coronaviruses was measured using the following synthetic quenched FRET peptide: CP488-ESATLQSGLRKAK- (CPQ2)-NH2 (CPC Scientific, San Jose, CA, USA).

    Published On: July 18th, 2024Categories: Citations, Dye-Labeled, FRET Substrates
  • Discovery of a new class of cell-penetrating peptides by novel phage display platform.

    Liu, J., Heddleston, J., Perkins, D.R., Chen, J.J.H., Ghanbarpour, A., Smith, B.W., Miles, R., Aihara, E. and Afshar, S. Scientific Reports 14, no. 1 (2024): 13437.

    1. Protein Engineering, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, CA, 92121, USA
    2. Biotechnology Research, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN, 46221, USA
    3. Genetic Medicine, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN, 46221, USA

    Synthetic peptides were ordered from CPC scientific with > 95% purity. NNJA peptides in the formats of monomer or dendrimer were conjugated by click chemistry to siRNA targeting hypoxanthine–guanine phosphoribosyltransferase (HPRT) gene [..]

    Published On: June 11th, 2024Categories: Citations, Click Peptides, Peptide-Oligonucleotide Conjugates
  • Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic.

    Shurtleff, V.W., Layton, M.E., Parish, C.A., Perkins, J.J., Schreier, J.D., Wang, Y., Adam, G.C., Alvarez, N., Bahmanjah, S., Bahnck-Teets, C.M. and Boyce, C.W. Journal of Medicinal Chemistry 67, no. 5 (2024): 3935-3958.

    1. Center for Discovery and Innovation, Hackensack Meridian Health. 111 Ideation Way. Nutley, New Jersey 07110, United States.
    2. Merck & Co., Inc., Rahway, New Jersey 07065, United States.

    The enzymatic activity of recombinantly expressed 3CLPro enzymes from different coronaviruses was measured using the following synthetic quenched FRET peptide: CP488-ESATLQSGLRKAK- (CPQ2)-NH2 (CPC Scientific, San Jose, CA.

    Published On: February 16th, 2024Categories: Citations, COVID-19, Dye-Labeled, FRET Substrates
  • Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists.

    Chandramohan, A., Josien, H., Yuen, T.Y., Duggal, R., Spiegelberg, D., Yan, L., Juang, Y.C.A., Ge, L., Aronica, P.G., Kaan, H.Y.K. and Lim, Y.H. Nature Communications 15, no. 1 (2024): 489.

    1. Merck & Co., Inc., Kenilworth, NJ 07033, USA.
    2. Merck & Co., Inc., Boston, MA 02115, USA
    3. Merck & Co., Inc., West Point, PA 19486, USA
    4. Genentech, South San Francisco, CA 94080, USA

    We thank Evans (Chen) Ge, Mike (Dixin) Xue, and Simon (Junhua) Li at Chinese Peptide Company (CPC) for peptide synthesis support.

    Published On: January 12th, 2024Categories: Citations, Click Peptides, Stapled Peptides, Unnatural Amino Acids
  • Discovery of a novel series of medium-sized cyclic enteropeptidase inhibitors.

    Kikuchi, F., Ikeda, Z., Kakegawa, K., Nishikawa, Y., Sasaki, S., Fukuda, K., Takami, K., Banno, Y., Nishikawa, H., Taya, N. and Nakahata, T. Bioorganic & Medicinal Chemistry 93 (2023): 117462.

    • Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan
    • Pharmaceutical Sciences, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan

    5FAM-Abu-Gly-Asp-Asp-Asp-Lys-Ile-Val-Gly-Gly-Lys(CPQ2)-Lys-Lys-NH2 (purity: 97.2%, CPC Scientific, Inc.) was diluted with an assay buffer to prepare a 5.4 μM substrate solution.

    Published On: August 29th, 2023Categories: Citations, Dye-Labeled, FRET Substrates
  • A covalent BTK ternary complex compatible with targeted protein degradation.

    Schiemer, J., Maxwell, A., Horst, R., Liu, S., Uccello, D.P., Borzilleri, K., Rajamohan, N., Brown, M.F. and Calabrese, M.F. Nature Communications 14, no. 1 (2023): 1189.

    • Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT, USA

    After 3 h the resin was washed with binding buffer until no protein was detected, followed by elution with 0.2 mg ml−1 FLAG peptide DYKDDDDK (CPC Scientific Peptide company)

    Published On: March 1st, 2023Categories: Citations
  • Development of a selective, sensitive and robust oxyntomodulin dual monoclonal antibody immunoassay.

    Umberger, T.S., Ming, W., Cox, J.M., Konrad, R.J. and Siegel, R.W. Bioanalysis 14, no. 18 (2022): 1229-1239.

    • Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, IN46285, USA

    Human K2 EDTA and P800 plasma (500 μl) was spiked with proglucagon 33–61, 35–61 and 36–61 stable-isotope-labeled internal standard peptides (CPC Scientific, custom order) and diluted with I buffer (25 mmol/l Tris-HCl, 25 mmol/l HEPES, 300 mmol/l NaCl, 0.1% (v/v) octyl β-D-glucopyranoside, pH 7.5).

    Published On: November 15th, 2022Categories: Citations, Isotope-Labeled Peptides
  • Activation of the human insulin receptor by non-insulin-related peptides.

    Kirk, N.S., Chen, Q., Wu, Y.G., Asante, A.L., Hu, H., Espinosa, J.F., Martínez-Olid, F., Margetts, M.B., Mohammed, F.A., Kiselyov, V.V. and Barrett, D.G. Nature Communications 13, no. 1 (2022): 5695.

    • Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.

    Peptides were synthesized under contract by CPC Scientific, except for the N-terminally acetylated version of IM172N22 and the Glu3Arg, Glu3Ala, Glu4Arg, Glu4Ala, Glu5Ala, Glu5Arg, Trp6Ala, Gln8Ala, Ile9Ala, Glu10Ala, Glu10Arg and Tyr14Ala mutants of IM172N22

    Published On: September 12th, 2022Categories: Citations
  • LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept.

    Coskun, T., Urva, S., Roell, W.C., Qu, H., Loghin, C., Moyers, J.S., O’Farrell, L.S., Briere, D.A., Sloop, K.W., Thomas, M.K. and Pirro, V. Cell Metabolism 34, no. 9 (2022): 1234-1247.

    • Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA

    Homologous and heterologous competition experiments were performed with non-radioactive peptide analogues[127I]-Tyr1-GIP(1-42) and [127]-Tyr10-GIP(1-42) to ensure quantification of the high-affinity binding site of the GIPR. Peptide analogues were generated using synthetic [127I]-Tyr amino acid building blocks (CPC Scientific).

    Published On: September 6th, 2022Categories: Citations, Isotope-Labeled Peptides
  • Anti-tumor activity of a T-helper 1 multiantigen vaccine in a murine model of prostate cancer.

    Cecil, D.L., Curtis, B., Gad, E., Gormley, M., Timms, A.E., Corulli, L., Bos, R., Damle, R.N., Sepulveda, M.A. and Disis, M.L. Scientific Reports 12, no. 1 (2022): 13618.

    1. Cancer Vaccine Institute, University of Washington, 850 Republican Street, Brotman Bld., 2nd Floor, Box 358050, Seattle, WA 98195-8050, USA.
    2. Janssen Research and Development LLC, Spring House, PA, USA.
    3. Janssen Vaccines and Prevention, Leiden, The Netherlands.

    The peptides were constructed and purified by high-performance liquid chromatography (> 90% pure; CPC Scientific).

    Published On: August 10th, 2022Categories: Citations
  • Design, Synthesis, and Biological Evaluation of a Novel Series of 4-Guanidinobenzoate Derivatives as Enteropeptidase Inhibitors with Low Systemic Exposure for the Treatment of Obesity.

    Ikeda, Z., Kakegawa, K., Kikuchi, F., Itono, S., Oki, H., Yashiro, H., Hiyoshi, H., Tsuchimori, K., Hamagami, K., Watanabe, M. and Sasaki, M. Journal of Medicinal Chemistry 65, no. 12 (2022): 8456-8477.

    • Research, Takeda Pharmaceutical Company Limited, 26-1, Muraokahigashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan

    Subsequently, 5FAM–Abu–Gly–Asp–Asp–Asp–Lys–Ile–Val–Gly–Gly–Lys(CPQ2)–Lys–Lys–NH2 (purity: 97.2%, CPC Scientific, Inc.) was diluted with an assay buffer to prepare a 2.1 μM substrate solution.

    Published On: June 10th, 2022Categories: Citations, Dye-Labeled, FRET Substrates, Unnatural Amino Acids
  • Comprehensive insulin receptor phosphorylation dynamics profiled by mass spectrometry.

    Liao, Z., Zhang, C., Ding, L., Moyers, J.S., Tang, J.X. and Beals, J.M. The FEBS Journal 289, no. 9 (2022): 2657-2671.

    • Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA.

    Synthetic peptides of hIR-B were purchased from CPC Scientific..

    Published On: November 26th, 2021Categories: Citations
  • Inhibition of Escherichia coli lipoprotein diacylglyceryl transferase is insensitive to resistance caused by deletion of Braun’s lipoprotein.

    Diao, J., Komura, R., Sano, T., Pantua, H., Storek, K.M., Inaba, H., Ogawa, H., Noland, C.L., Peng, Y., Gloor, S.L. and Yan, D. Journal of Bacteriology 203, no. 13 (2021): 10-1128.

    • Departments of Infectious Diseases, Structural Biology, Biochemical and Cellular Pharmacology, Translational Immunology, Pathology, Protein Chemistry, Early Discovery Biochemistry, Genentech, South San Francisco, California, USA

    For the Lgt biochemical assay, the Pal-IAAC and Pal-IAAA peptides were synthesized by CPC Scientific.

    Published On: June 8th, 2021Categories: Citations, Lipidation
  • An integrated genomic, proteomic, and immunopeptidomic approach to discover treatment-induced neoantigens.

    Olsson, N., Heberling, M.L., Zhang, L., Jhunjhunwala, S., Phung, Q.T., Lin, S., Anania, V.G., Lill, J.R. and Elias, J.E. Frontiers in Immunology 12 (2021): 662443.

    • Department of Microchemistry, Proteomics and Lipidomics, Genentech, South San Francisco, CA, United States
    • Department of OMNI Biomarker Development, Genentech, South San Francisco, CA, United States

    In total 30 synthetic peptides covering a total of 22 SNP sites and two potential neoantigens, were purchased from CPC Scientific (Sunnyvale, CA) with a purity of >70%, dissolved in 0.1% FA and quality checked at a concentration of 250 fmol by mass spectrometry.

    Published On: April 14th, 2021Categories: Citations
  • Discovery of an Orally Efficacious Positive Allosteric Modulator of the Glucagon-like Peptide-1 Receptor.

    Willard, F.S., Wainscott, D.B., Showalter, A.D., Stutsman, C., Ma, W., Cardona, G.R., Zink, R.W., Corkins, C.M., Chen, Q., Yumibe, N. and Agejas, J. Journal of Medicinal Chemistry 64, no. 6 (2021): 3439-3448

    1. Discovery Chemistry Research and Technologies, Diabetes and Complications, Investigative Drug Disposition, Lilly Research Laboratories, Indianapolis, IN 46285 and S2.
    2. Discovery Chemistry Research and Technologies, Lilly, S.A., Avda. de la Industria 30, 28108 Alcobendas, Madrid, Spain.

    Synthetic peptides were synthesized at Eli Lilly, Bachem (Torrance, CA), or CPC Scientific (Sunnyvale, CA) to >95% purity.

    Published On: March 15th, 2021Categories: Citations
  • Longitudinal CSF proteomics identifies NPTX2 as a prognostic biomarker of Alzheimer’s disease.

    Libiger, O., Shaw, L.M., Watson, M.H., Nairn, A.C., Umaña, K.L., Biarnes, M.C., Canet‐Avilés, R.M., Jack Jr, C.R., Breton, Y.A., Cortes, L. and Chelsky, D. Alzheimer's & Dementia 17, no. 12 (2021): 1976-1987.

    1. Janssen Research and Development, 3210 Merryfield Row, San Diego, CA 92121, USA.
    2. Foundation for the National Institutes of Health, North Bethesda, Maryland, USA
    3. Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA
    4. Merck & Co., Inc., West Point, Pennsylvania, USA

    Purified synthetic stable isotope (15N and 13C) labeled (SIL) peptides were from CPC Scientific (EDSLEAGLPLQVR [CMGA]; SLGVGFATR [FABPH]; VLEYLNQEK [SCG2]; and THLGEALAPLSK [VGF]); and JPT Peptide Technologies (TNYLYGK [NPTX2]).

    Published On: March 13th, 2021Categories: Citations, Isotope-Labeled Peptides
  • Novel inhibitors of E. coli lipoprotein diacylglyceryl transferase are insensitive to resistance caused by lpp deletion

    Diao, J., Komura, R., Sano, T., Pantua, H., Storek, K.M., Inaba, H., Ogawa, H., Noland, C.L., Peng, Y., Gloor, S.L. and Yan, D. bioRxiv (2020): 2020-10.

    • Departments of Infectious Diseases, Structural Biology, Biochemical and Cellular Pharmacology, Translational Immunology, Pathology, and Early Discovery Biochemistry, Genentech, South San Francisco, CA 94080 USA

    The standard assay consists of 6 μL reaction mixture with 3 nM Lgt-DDM, 50 μM phosphatidylglycerol (1,2-dipalmitoyl-sn-glycero-3-phospho-(1’-rac-glycerol), Avanti), 12.5 μM Pal-IAAC peptide substrate derived from the Pal lipoprotein (MQLNKVLKGLMIALPVMAIAACSSNKN, synthesized by CPC Scientific)

    Published On: October 5th, 2020Categories: Citations
  • Unstable Mechanisms of Resistance to Inhibitors of Escherichia coli Lipoprotein Signal Peptidase.

    Pantua, H., Skippington, E., Braun, M.G., Noland, C.L., Diao, J., Peng, Y., Gloor, S.L., Yan, D., Kang, J., Katakam, A.K. and Reeder, J. MBio 11, no. 5 (2020): 10-1128.

    • Departments of Infectious Diseases, OMNI Bioinformatics, Chemistry, Structural Biology, Biochemical and Cellular Pharmacology, Translational Immunology, Pathology, Molecular Biology, Genentech, South San Francisco, California, USA

    MQLNKV-L(U13C6,15N)-KGL(U13C6,15N)MIALPVMAIAA-dipalmitoyl2C-SSNKNGG-K-biotin, which upon cleavage by LspA, yields the product peptide dipalmitoyl2C-SSNKNGG-K-biotin. A product standard [dipalmitoyl2C-SSNKNAAK-(NHCH2CH2NH)-biotin; CPC Scientific] was in the reaction mixture as an internal standard for normalization of product quantitation.

    Published On: September 8th, 2020Categories: Citations, Isotope-Labeled Peptides, Lipidation
  • Structure of the essential inner membrane lipopolysaccharide–PbgA complex.

    Clairfeuille, T., Buchholz, K.R., Li, Q., Verschueren, E., Liu, P., Sangaraju, D., Park, S., Noland, C.L., Storek, K.M., Nickerson, N.N. and Martin, L. Nature 584, no. 7821 (2020): 479-483.

    • Departments of Structural Biology, Infectious Diseases, Microchemistry, Proteomics & Lipidomics, Drug Metabolism & Pharmacokinetics, Translational Immunology, BioMolecular Resources, Biochemical & Cellular Pharmacology, Bioinformatics & Computational Biology, Discovery Chemistry Departments, Genentech Inc., South San Francisco, CA, USA.

    LAB peptides ([..], CPC Scientific, [..] l, standard solid-phase peptide synthesis) at 10 mM in 50 mM Tris, pH 8, and 100 mM NaCl were diluted in MHB II cation adjusted broth (800 μM top concentration) or LB. Where indicated, EDTA was added to a final concentration of 0.5 mM.

    Published On: August 12th, 2020Categories: Citations
  • Structural insights into probe-dependent positive allosterism of the GLP-1 receptor.

    Bueno, A.B., Sun, B., Willard, F.S., Feng, D., Ho, J.D., Wainscott, D.B., Showalter, A.D., Vieth, M., Chen, Q., Stutsman, C. and Chau, B. Nature Chemical Biology 16, no. 10 (2020): 1105-1110.

    1. Lilly, S.A., Alcobendas, Spain.
    2. ConfometRx, Santa Clara, CA, USA.
    3. Departments of Quantitative Biology, Discovery Chemistry Research and Technologies, and Diabetes and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA.
    4. Lilly Biotechnology Center San Diego, San Diego, CA, USA.

    Peptides were synthesized and purified to >95% purity at Eli Lilly and Company or purchased from CPC Scientific or Tocris. GLP-1(9-36)NH2, GLP-1(7-36)NH2, OXM(1-37)OH and GIP(1-42)NH2 were used for pharmacology experiments, and GLP-1(7-37)OH was used for cryo-EM studies.

    Published On: July 20th, 2020Categories: Citations
  • Integration of phage and yeast display platforms: A reliable and cost effective approach for binning of peptides as displayed on-phage.

    Pandya, P., Sayers, R.O., Ting, J.P., Morshedian, S., Torres, C., Cudal, J.S., Zhang, K., Fitchett, J.R., Zhang, Q., Zhang, F.F. and Wang, J. PLoS One 15, no. 6 (2020): e0233961.

    1. Departments of Protein Engineering, Eli Lilly Biotechnology Center, Discovery Chemistry Research and Technologies, San Diego, California, United States of America
    2. Departments of Structural Biology, Quantitative Biology, and Recombinant Protein Generation, Discovery Chemistry Research and Technologies, and, Eli Lilly and Company, Indianapolis, Indiana, United States of America
    3. Centro de Investigacio´n Lilly, Alcobendas, Spain

    Peptide synthesis was outsourced to CPC Scientific.

    Published On: June 1st, 2020Categories: Citations
  • Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics.

    Froning, K., Maguire, J., Sereno, A., Huang, F., Chang, S., Weichert, K., Frommelt, A.J., Dong, J., Wu, X., Austin, H. and Conner, E.M. Nature Communications 11, no. 1 (2020): 2330.

    • Eli Lilly Biotechnology Center, 10300 Campus Point Drive, San Diego, CA 92121, USA

    SLLMWITQC (NY-ESO-1) peptide (synthesized by CPC Scientific), 100 μL total volume, for 3 h.

    Published On: May 11th, 2020Categories: Citations
  • Discovery and characterization of a small‐molecule enteropeptidase inhibitor, SCO‐792.

    Sasaki, Masako, Ken‐ichi Hamagami et al. Pharmacology Research & Perspectives 7, no. 5 (2019): e00517.

    • Research, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

    The substrates QSY21‐Gly‐Asp‐Asp‐Asp‐Lys‐Ile‐Val‐Gly‐Gly‐Lys(Cy5) and 5FAM‐Abu‐Gly‐Asp‐Asp‐Asp‐Lys‐Ile‐Val‐Gly‐Gly‐Lys(CPQ2)‐Lys‐Lys‐NH2 were purchased from CPC Scientific (Sunnyvale, CA).

    Published On: February 7th, 2019Categories: Citations, Dye-Labeled, FRET Substrates
  • Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.

    Hewings, D.S., Heideker, J., Ma, T.P., AhYoung, A.P., El Oualid, F., Amore, A., Costakes, G.T., Kirchhofer, D., Brasher, B., Pillow, T. and Popovych, N. Nature Communications 9, no. 1 (2018): 1162.

    • Discovery Oncology, Genentech, South San Francisco, California, 94080, USA
    • Early Discovery Biochemistry, Genentech, South San Francisco, California, 94080, USA

    The 5-TAMRA (5-Carboxytetramethylrhodamine) peptide was generated by CPC-Scientific consisting of the sequence 5-TAMRA-YPYDVPDYAIREIVSRNKRRYQEDG. K63 or K48 tetra-Ub chains were conjugated to the peptide via its lysine residue [..]

    Published On: March 21st, 2018Categories: Citations, Dye-Labeled
  • USP7 small-molecule inhibitors interfere with ubiquitin binding.

    Kategaya, L., Di Lello, P., Rougé, L., Pastor, R., Clark, K.R., Drummond, J., Kleinheinz, T., Lin, E., Upton, J.P., Prakash, S. and Heideker, J. Nature 550.7677 (2017): 534.

    1. Departments of Discovery Oncology, Early Discovery Biochemistry, Structural Biology, Discovery Chemistry, Biochemical and Cellular Pharmacology, Protein Chemistry, Microchemistry, Proteomics, and Lipidomics, Research Pathology, Bioinformatics and Computational Biology, and Translational Oncology, Genentech, South San Francisco, 94080, California, USA
    2. Department of Pharmaceutical Chemistry and Small Molecule Discovery Center, University of California, San Francisco, San Francisco, 94143, California, USA
    3. MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK
    4. Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, NE2 1HH, UK

    "The 5-TAMRA (5-carboxytetramethylrhodamine) peptide was generated by CPCScientific consisting of the sequence 5-TAMRA-YPYDVPDYAIREIVSRNKRRYQEDG.."

    Published On: October 26th, 2017Categories: Citations, Dye-Labeled
  • Discovery of potent and orally bioavailable macrocyclic peptide-peptoid hybrid CXCR7 modulators.

    Boehm, M., Beaumont, K., Jones, R.M., Kalgutkar, A.S., Zhang, L., Atkinson, K., Bai, G., Brown, J.A., Eng, H., Goetz, G.H. and Holder, B.R. Journal of Medicinal Chemistry (2017).

    1. Pfizer Worldwide Research & Development, Cambridge, Massachusetts 02139, United States
    2. Pfizer Worldwide Research & Development, Groton, Connecticut 06340, United States

    The chemokine receptor CXCR7 is an attractive target for a variety of diseases. While several small-molecule modulators of CXCR7 have been reported, peptidic macrocycles may provide advantages in terms of potency, selectivity, and reduced off-target activity

    Published On: October 18th, 2017Categories: Citations, Peptoids
  • Selective Homogeneous Assay for Circulating Endopeptidase Fibroblast Activation Protein (FAP).

    Bainbridge, Travis W., et al. Scientific Reports 7.1 (2017): 12524.

    • Protein Chemistry, Molecular Oncology, Discovery Chemistry, Cancer Immunology, and Neuroscience. Genentech Inc., South San Francisco, CA, 94080, USA

    "ANP FAP and aP NIRF were synthesized by CPC Scientific (Sunnyvale, CA)… Another internally-quenched FRET peptide substrate (ANPFAP) for FAP has recently been reported and demonstrated for use as an activity-based, in vivo imaging tool. The peptide sequence contains two internal Gly-Pro dipeptide motifs, susceptible to FAP cleavage and a Cy5.5/QSY21, quenched-FRET pair."

    Published On: October 2nd, 2017Categories: Citations, Dye-Labeled, FRET Substrates
  • Time-dependent inhibition of PHD2.

    Tcholakov, I., Grimshaw, C.E., Shi, L., Kiryanov, A., Murphy, S.T., Larson, C.J., Plonowski, A. and Ermolieff, J. Bioscience Reports 37, no. 3 (2017): BSR20170275.

    • Departments of In Vitro Pharmacology, Immunology, Enzymology and Biophysical Chemistry, Medicinal Chemistry, External Innovation, Metabolic Disease, In Vitro Pharmacology, and Gastrointestinal and Enterology Discovery Unit, Takeda California, Inc., 10410 Science Center Drive, San Diego, CA 92121, U.S.A

    The substrate used for our PHD2 kinetic study was a 17-mer peptide mimicking the sequence of HIF-1a surrounding the Pro564 residue hydroxylated by the PHD enzymes (Biotin-DLEMLAPYIPMDDDFQL). The substrate used for FIH1 was a 34-mer peptide mimicking the sequence of HIF-1α surrounding residue Asn803 (DESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRAL). Both peptides were synthesized by CPC Scientific Inc.

    Published On: June 30th, 2017Categories: Citations
  • Multivalent peptidic linker enables identification of preferred sites of conjugation for a potent thialanstatin antibody drug conjugate.

    Puthenveetil, Sujiet, et al. PloS One 12.5 (2017): e0178452.

    1. Worldwide Medicinal Chemistry, Pfizer Global R&D, Groton, Connecticut, United States of America.
    2. Pfizer Oncology Research, Pearl River, NY, United States of America.

    "Peptide-payload conjugate (7) was prepared by reacting 2mM aizoacetyl-Ser-Lys-Gly-Ser-Lys (CPC scientific, inc. Sunnywale, CA) with 8 mM NHS-ester payload [19] in 50% Dimethyl sulfoxide (DMSO), 50 mM borate buffer pH 8.5 for 2 h at 37°C."

    Published On: May 30th, 2017Categories: Citations, Click Peptides
  • Structural insights into lipoprotein N-acylation by Escherichia coli apolipoprotein N-acyltransferase.

    Noland, Cameron L., et al. Proceedings of the National Academy of Sciences 114.30 (2017): E6044-E6053.

    • Departments of Structural Biology, Infectious Diseases, Biochemical and Cellular Pharmacology, Pathology, Translational Immunology, and Biomolecular Resource Group, Genentech, Inc., South San Francisco, CA 94080.

    "..peptide substrates were synthesized based on the Pal lipoprotein, Pal peptideshort (Pam2Cys-SSNKNGGK-Biotin; CPC Scientific, Inc.).."

    Published On: May 10th, 2017Categories: Citations, Lipidation, Showcase Lipidation
  • Inhibition of factor XIa reduces the frequency of cerebral microembolic signals derived from carotid arterial thrombosis in rabbits.

    Wang, X., Kurowski, S., Wu, W., Castriota, G.A., Zhou, X., Chu, L., Ellsworth, K.P., Chu, D., Edmondson, S., Ali, A. and Andre, P. Journal of Pharmacology and Experimental Therapeutics 360, no. 3 (2017): 476-483.

    1. Departments of Cardiometabolic Disease Biology, Discovery Pharmaceutical Sciences, In Vitro Pharmacology, and Discovery Chemistry, Merck Research Laboratories, Kenilworth, New Jersey.
    2. Lead Optimization Chemistry, Merck Research Laboratories, Rahway, New Jersey.

    The 7-amido-4-thifluoromethylcoumarin (AFC) containing fluorescence substrate, CH3SO2-cyclohexyl-Gly-Gly-Arg-AFC (cyclohexyl-G-G-R-AFC) was custom synthesized by CPC Scientific (Sunnyvale, CA, USA)..

    Published On: March 1st, 2017Categories: Citations, Dye-Labeled, Unnatural Amino Acids
  • Factor XIIa as a novel target for thrombosis: target engagement requirement and efficacy in a rabbit model of microembolic signals.

    Barbieri, Christopher M., et al. Journal of Pharmacology and Experimental Therapeutics 360.3 (2017): 466-475.

    • In Vitro Pharmacology and Cardiometabolic Diseases, Merck & Co., Inc., Kenilworth, New Jersey

    "The 7-amido-4-thifluoromethylcoumarin (AFC) containing fluorescence substrate, CH3SO2-cyclohexyl-Gly-Gly-Arg-AFC (cyclohexylG-G-R-AFC) was custom synthesized by CPC Scientific (Sunnyvale, CA, USA)"

    Published On: February 10th, 2017Categories: Citations, Dye-Labeled, Unnatural Amino Acids
  • Improved variants of SrtA for site-specific conjugation on antibodies and proteins with high efficiency.

    Chen, Long, et al. Scientific Reports 6 (2016).

    1. Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, Peking University, Beijing 100871, China
    2. Department of Global Biotherapeutics Technologies, Pfizer Inc., Cambridge, MA 02140, USA
    3. School of Life Sciences, Nanjing University, China
    4. Peking-Tsinghua Center for Life Sciences, Beijing, China

    "The Biotin-C6-LELPETGG-NH2, GGGY-Lys(Biotin)-NH2, and GGG-Lys(N3)-NH2 reagents were synthesized by CPC Scientific."

    Published On: August 18th, 2016Categories: Citations, Click Peptides, Unnatural Amino Acids
  • Identification of a novel BODIPY minihepcidin tool for the high content analysis of Ferroportin (SLC40A1) pharmacology.

    Skerratt, Sarah E., Sian Humphreys, Rita Ferreira, Csilla Jorgensen, Joe Warmus, Lei Zhao, Xiaohe Tong, and Sarah A. Nickolls. MedChemComm 7, no. 8 (2016): 1564-1571.

    1. Pfizer Neusentis, The Portway Building, Granta Park, Cambridge, UK.
    2. Pfizer Worldwide Research & Development, Eastern Point Road, Groton, Connecticut 06340, USA.
    3. CPC Scientific Inc., 1245 Reamwood Avenue, Sunnyvale, CA 94089, USA.

    "antipeptide (EGVYVHPV), angiotensin II, human (DRVYIHPF), and isotopically (13C) labeled heptapeptide (AAAAHAA-NH2 [where “A” indicates a carbon thirteen (13C) "Synthesis was conducted at CPC Scientific Inc. Ac-Asp(OtBu)-Thr(tBu)-His(Trt)-Phe-Pro-Ile-Cys(Trt)-Ile-PhePEG3-Arg(Pbf)-Arg(Pbf)-Lys(Boc)-wang resin (2).. Ac-Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-PEG3-Arg-Arg-Lys(BODIPY_TMR_C6)."

    Published On: August 1st, 2016Categories: Citations, coauthored, Metal Chelates, PEGylation, publications
  • Development and validation of an IA-LC/MS method to quantitate active and total B-type natriuretic peptide in human plasma.

    Chappell, D.L., Lee, A.Y., Bernstein, H.S., Lassman, M.E. and Laterza, O.F. Bioanalysis 8, no. 22 (2016): 2341-2349.

    • Merck & Co., Inc. Rahway, NJ07065, USA
    Published On: July 15th, 2016Categories: Citations
  • Engineering highly potent and selective microproteins against Nav1. 7 sodium channel for treatment of pain.”

    Shcherbatko, Anatoly, Andrea Rossi, Davide Foletti, Guoyun Zhu, Oren Bogin, Meritxell Galindo Casas, Mathias Rickert et al. Journal of Biological Chemistry 291, no. 27 (2016): 13974-13986.

    • Rinat Laboratories, Pfizer Inc., South San Francisco, California 94080

    Large scale preparations were performed based on the described protocol by CPC Scientific.

    Published On: July 1st, 2016Categories: Citations
  • Characterization and quantification of oxyntomodulin in human and rat plasma using high-resolution accurate mass LC-MS.

    Cox, J.M., Berna, M.J., Jin, Z., Cox, A.L., Sloop, K.W., Gutierrez, J.A. and Ackermann, B.L. Bioanalysis 8, no. 15 (2016): 1579-1595.

    • 1 Lilly Research Laboratories, Eli Lilly & Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.

    "The OXM peptides 1–37, 3–37 and 4–37 as well as their corresponding stable isotope-labeled internal standards (each containing one [ 13 C 9 , 15 N]-labeled phenylalanine and two [ 13 C 6 , 15 N]-labeled leucine residues) were synthesized by CPC Scientific, Inc."

    Published On: June 17th, 2016Categories: Citations, Isotope-Labeled Peptides
  • Effects of KLK Peptide on Adjuvanticity of Different ODN Sequences

    Chikh, G., Luu, R., Patel, S., Davis, H.L. and Weeratna, R.D. Vaccines 4, no. 2 (2016): 14.

    • Pfizer Vaccine Immunotherapeutics, Ottawa Laboratories, Ottawa, ON K2K 3A2, Canada

    KLK peptide (KLKL5KLK) and KPK peptide (KPKP5KPK) were synthesized by CPC Scientific, San Jose, CA, USA.

    Published On: May 4th, 2016Categories: Citations
  • Circulating FGF21 Proteolytic Processing Mediated by Fibroblast Activation Protein.

    Zhen, Eugene Y., et al. Biochemical Journal (2015): BJ20151085.

    • Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, U.S.A

    "Stable isotope-labelled (SIL) peptides were synthesized by CPC Scientific. Leucine residues were selectively labeled using 13C/15N-labelled amino acids resulting in the addition of 7 Da to the peptide mass (Supplementary Table S1). The reported purity of each synthesized peptide was more than 95% based on HPLC analysis. "

    Published On: February 24th, 2016Categories: Citations, Isotope-Labeled Peptides
  • Multiplexed quantification of proglucagon-derived peptides by immunoaffinity enrichment and tandem mass spectrometry after a meal tolerance test.

    Lopez, A., Reyna, D.E., Gitego, N. et al. Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer. Nat Commun 13, 1199 (2022).

    • Cardio-metabolic Disease Biomarkers, Merck Research Laboratories, Kenilworth, NJ., Merck & Co., Inc.

    "Glucagon synthetic peptide and heavy isotope–labeled internal standards (ISs) of oxyntomodulin and glucagon containing 2 [ 13 C 6 - 15 N]-labeled leucines and 1 [ 13 C 9 - 15 N]-labeled phenylalanine were synthesized by CPC Scientific.."

    Published On: December 10th, 2015Categories: Citations, Isotope-Labeled Peptides
  • Mitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical Utility.

    Martinez, R., Blasina, A., Hallin, J.F., Hu, W., Rymer, I., Fan, J., Hoffman, R.L., Murphy, S., Marx, M., Yanochko, G. and Trajkovic, D. PloS One 10, no. 9 (2015): e0138616.

    • Oncology Research Unit, Pfizer Worldwide Research and Development, 10724 Science Center Drive, San Diego, CA, 92121

    The 60 minute enzymatic reaction contained 5 nM Mps1 catalytic domain (aa 510–857), 60 μM (~Km-level) ATP, 5 μM phosphoacceptor peptide substrate (5FAM-RQRRSIDDTIDSTRLFE-NH2; CPC Scientific, Sunnyvale, CA), 10 mM MgCl2, 4% DMSO (with or without inhibitor), 1 mM DTT, 0.01% Tween-20, 50 mM HEPES (pH 7.5).

    Published On: September 23rd, 2015Categories: Citations, Dye-Labeled
  • Comparison of a High-Throughput Mass Spectrometry Method and Radioactive Filter Binding to Assay the Protein Methyltransferase PRMT5

    Maegley, K.A., Krivacic, C., Bingham, P., Liu, W. and Brooun, A. ASSAY and Drug Development Technologies 13, no. 4 (2015): 235-240.

    • Oncology Research Unit and 2 Oncology Medicinal Chemistry, Pfizer World Wide Research and Development, San Diego, California.

    MS solvents were purchased from Sigma and Burdick & Jackson. Custom peptides were synthesized by CPC Scientific.

    Published On: June 12th, 2015Categories: Citations
  • Acute hemodynamic and renal effects of glucagon-like peptide 1 analog and dipeptidyl peptidase-4 inhibitor in rats.

    Zhou, X., Huang, C.H., Lao, J., Pocai, A., Forrest, G., Price, O., Roy, S., Kelley, D.E., Sullivan, K.A. and Forrest, M.J. Cardiovascular Diabetology 14 (2015): 1-10.

    • Departments of Cardiometabolic Diseases and In Vivo Pharmacology, Merck Research Laboratories, 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA

    GLP-1 was purchased from CPC Scientific (San Jose, California). MK-0626 was synthesized by Merck & Co., Inc.

    Published On: March 7th, 2015Categories: Citations
  • Axitinib effectively inhibits BCR-ABL1 (T315I) with a distinct binding conformation.

    Pemovska, T., Johnson, E., Kontro, M., Repasky, G.A., Chen, J., Wells, P., Cronin, C.N., McTigue, M., Kallioniemi, O., Porkka, K. and Murray, B.W. Nature 519, no. 7541 (2015): 102-105.

    • La Jolla Laboratories, Pfizer Worldwide Research & Development, San Diego, California 92121, USA.

    The reactions were conducted in 50 ml volumes in 96-well plates and contained GST-tagged human-recombinant ABL1(T315I) kinase intracellular domain (1 nM), 3 mM phosphoacceptor peptide, 59 FAM- EAIYAAPFAKKK-OH (CPC Scientific, also known as ProfilerPro Peptide 2, Caliper Life Sciences), test compound (11-dose threefold serial dilutions, 2% DMSO final) or DMSO only, 1 mM dithiothreitol (DTT), 0.002% Tween-20 and 5 mM MgCl2 in 25 mM HEPES, pH 7.1

    Published On: February 9th, 2015Categories: Citations, Dye-Labeled
  • Residence time and kinetic efficiency analysis of extracellular signal-regulated kinase 2 inhibitors.

    Vanderpool, D., Grimshaw, C.E., Lawson, J.D. and Ermolieff, J. Analytical Biochemistry 473 (2015): 46-52.

    • Enzymology and Biophysical Chemistry Group, Takeda California, San Diego, CA 92121, USA
    • Computational Sciences and Crystallography Group, Takeda California, San Diego, CA 92121, USA

    The mobility shift assay substrate (5-FAM-IPTSPITTTYFFFKKK) was purchased from CPC Scientific (Sunnyvale, CA, USA).

    Published On: December 20th, 2014Categories: Citations, Dye-Labeled
  • Use of high-throughput mass spectrometry to reduce false positives in protease uHTS screens.

    Adam, G.C., Meng, J., Rizzo, J.M., Amoss, A., Lusen, J.W., Patel, A., Riley, D., Hunt, R., Zuck, P., Johnson, E.N. and Uebele, V.N. Journal of Biomolecular Screening 20, no. 2 (2015): 212-222.

    • Screening and Protein Sciences, Merck Research Labs, North Wales, PA, USA

    Plates were incubated for 210 min at 25 °C followed by quenching with 25 uL water with 2% formic acid containing 600 nM of the internal standard with the sequence KTEEISEVN[L-U7]-OH (CPC Scientific).

    Published On: October 21st, 2014Categories: Citations, Isotope-Labeled Peptides
  • Design of Potent and Selective Inhibitors to Overcome Clinical Anaplastic Lymphoma Kinase Mutations Resistant to Crizotinib.

    Huang, Q., Johnson, T.W., Bailey, S., Brooun, A., Bunker, K.D., Burke, B.J., Collins, M.R., Cook, A.S., Cui, J.J., Dack, K.N. and Deal, J.G. Journal of Medicinal Chemistry 57, no. 4 (2014): 1170-1187.

    • La Jolla Laboratories, Pfizer Worldwide Research and Development, 10770 Science Center Drive, San Diego, California 92121

    The reactions were conducted in 50-μL volumes in 96-well plates and contained 1.3 nM wild-type or 0.5 nM mutant ALK, 3 μM phosphoacceptor peptide (5′FAM-KKSRGDYMTMQIG-CONH2, synthesized by CPC Scientific, Sunnyvale, CA)..

    Published On: January 16th, 2014Categories: Citations, Dye-Labeled
  • Factor XIIa inhibition by Infestin-4: in vitro mode of action and in vivo antithrombotic benefit.

    Xu, Y., Cai, T.Q., Castriota, G., Zhou, Y., Hoos, L., Jochnowitz, N., Loewrigkeit, C., Cook, J.A., Wickham, A., Metzger, J.M. and Ogletree, M.L. Thrombosis and Haemostasis 111, no. 04 (2014): 694-704.

    • Departments of Thrombosis, Cardiometabolic Diseases and In Vivo Pharmacology, Merck Research Laboratories, Kenilworth, New Jersey, USA

    CHG-GR-AFC (CPC Scientific, Sunnyvale, CA, USA) was used for rabbit FIXa and FXa, and human activated protein C.

    Published On: December 12th, 2013Categories: Citations, Dye-Labeled
  • Discovery of Dap‑3 Polymyxin Analogues for the Treatment of Multidrug-Resistant Gram-Negative Nosocomial Infections.

    Magee, T.V., Brown, M.F., Starr, J.T., Ackley, D.C., Abramite, J.A., Aubrecht, J., Butler, A., Crandon, J.L., Dib-Hajj, F., Flanagan, M.E. and Granskog, K. Journal of Medicinal Chemistry 56, no. 12 (2013): 5079-5093.

    1. Pfizer Worldwide Research & Development, Pfizer, Inc., Groton, Connecticut 06340, United States
    2. CPC Scientific, Hangzhou, P.R. China
    Published On: June 4th, 2013Categories: Citations, coauthored, Peptide Macrocycles, publications, Unnatural Amino Acids
  • Substrate-Specific Conformational Regulation of the Receptor Tyrosine Kinase VEGFR2 Catalytic Domain.

    Solowiej, J., Chen, J.H., Zou, H.Y., Grant, S.K. and Murray, B.W. ACS Chemical Biology 8, no. 5 (2013): 978-986.

    • Oncology Research Unit, Pfizer Worldwide Research and Development, 10777 Science Center Drive, San Diego, California 92121, United States.

    EGFR2(786−805) peptide was synthesized and purified to 98% purity (CPC Scientific). Activation loop peptides were synthesized to >90% purity (Pfizer, La Jolla): VEGFR2 (Ac-LARDIYKDPDYVR-K KDR-tide); cMet (Ac-LARDMYDKEYYSK, METtide; MET2 Ac-ARDMYDKEYYSVHN-K). The C-terminal cMet peptide (Ac-ARDMYDKEYYSVHNK) was synthesized (Pfizer, La Jolla) to >90% purity.

    Published On: February 26th, 2013Categories: Citations
  • Quantification of circulating D-dimer by peptide immunoaffinity enrichment and tandem mass spectrometry.

    Wang, W., Walker, N.D., Zhu, L.J., Wu, W., Ge, L., Gutstein, D.E., Yates, N.A., Hendrickson, R.C., Ogletree, M.L., Cleary, M. and Opiteck. Analytical Chemistry 84.15 (2012): 6891-6898.

    • Departments of Molecular Biomarkers, Cardiovascular Diseases, and Clinical Pharmacology, Merck Research Laboratories, Rahway, New Jersey, United States.

    "Peptide Stable isotope–labeled internal standard peptide (Q 7 and K 15 reciprocally cross-linked dimer of LTIGEGQQHHL*GGAKQAGDV, where L* represents 13 C 6 , 15 N 1 -labeled leucine) was synthesized and analyzed for purity and amino acid content (CPC Scientific)"

    Published On: July 9th, 2012Categories: Citations, Isotope-Labeled Peptides, Peptide Macrocycles, Showcase Isotope-Labeled, Showcase Macrocycles
  • Osteopontin induces growth of metastatic tumors in a preclinical model of non-small lung cancer.

    Shojaei, Farbod, et al. Journal of Experimental & Clinical Cancer Research 31.1 (2012): 1.

    • Pfizer Global Research and Development, Department of Oncology, La Jolla, CA, USA

    "Epitope mapping studies were carried out using an overlapping series of synthetic peptides (CPC Scientific, CA) designed based on the primary sequence of OPN. Peptides corresponding to the region 143-172 of human OPN are listed below [..]"

    Published On: March 23rd, 2012Categories: Citations, Peptide Libraries
  • Supercritical fluid chromatographic resolution of water soluble isomeric carboxyl/amine terminated peptides facilitated via mobile phase water and ion pair formation.

    Patel, M. A., F. Riley, M. Ashraf-Khorassani, and L. T. Taylor. Journal of Chromatography A 1233 (2012): 85-90.

    • Global Research & Development, Pfizer, Inc., Groton, CT 06340, USA

    Uncapped peptides containing both an amine and carboxyl terminus were synthesized by CPC Scientific Inc. (San Jose, CA) for this research. The linear isomeric peptides exhibited high water solubility (e.g. 1 mg/mL).

    Published On: February 1st, 2012Categories: Citations
  • Single and Combination Herpes Simplex Virus Type 2 Glycoprotein Vaccines Adjuvanted with CpG Oligodeoxynucleotides or Monophosphoryl Lipid A Exhibit Differential Immunity That Is Not Correlated to Protection in Animal Models.

    Khodai, T., Chappell, D., Christy, C., Cockle, P., Eyles, J., Hammond, D., Gore, K., McCluskie, M.J., Evans, D.M., Lang, S. and Loudon, P.T. Clinical and Vaccine Immunology 18, no. 10 (2011): 1702-1709.

    • Vaccines Research Unit, Pfizer Research and Development, Sandwich, United Kingdom

    Peptides (CPC Scientific) representing selected sequences of gD and gB that had previously been demonstrated to contain T cell epitopes (data not shown) were synthesized as 15-mers, quality assessed, and formulated into pools representing each protein.

    Published On: September 1st, 2011Categories: Citations
  • SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

    Pacholec, M., Bleasdale, J.E., Chrunyk, B., Cunningham, D., Flynn, D., Garofalo, R.S., Griffith, D., Griffor, M., Loulakis, P., Pabst, B. and Qiu, X.Journal of Biological Chemistry 285, no. 11 (2010): 8340-8351.

    • Departments of Cardiovascular, Metabolic and Endocrine Diseases, and Structural Biology, Pfizer Global Research and Development, Groton, Connecticut 06340

    The p53-derived peptides, TAMRA-p53 peptide and native p53 peptide, were custom-synthesized by CPC Scientific.

    Published On: March 1st, 2010Categories: Citations, Dye-Labeled
  • Characterizing the Effects of the Juxtamembrane Domain on Vascular Endothelial Growth Factor Receptor-2 Enzymatic Activity, Autophosphorylation, and Inhibition by Axitinib.

    Solowiej, J., Bergqvist, S., McTigue, M.A., Marrone, T., Quenzer, T., Cobbs, M., Ryan, K., Kania, R.S., Diehl, W. and Murray, B.W. Biochemistry 48, no. 29 (2009): 7019-7031.

    • Pfizer Global Research and Development, La Jolla, Pfizer Inc., 10777 Science Center Drive, San Diego, California 92121.

    A peptide designed to encompass VEGFR2 residues 786-805 was synthesized and purified to 98% purity (CPC Scientific, San Jose, CA). Compounds were synthesized as described in patents: AG-13736 (35), AG-13974 (36), AG-28038 (35), and AG-28047 (37).

    Published On: June 15th, 2009Categories: Citations
  • Steady-State and Pre-Steady-State Kinetic Evaluation of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CLpro Cysteine Protease:  Development of an Ion-Pair Model for Catalysis.

    Solowiej, J., Thomson, J.A., Ryan, K., Luo, C., He, M., Lou, J. and Murray, B.W. Biochemistry 47, no. 8 (2008): 2617-2630.

    • Pfizer Global Research and DeVelopment, La Jolla, Pfizer Inc., 10777 Science Center Drive, San Diego, California 92121.

    Peptide 4 [Dabcyl-KTSAVLQSGFRKME-Edans], peptide 5 [SITSAVLQ-pNA], and peptide 6 [SITSAVLQ-pNP] were purchased from CPC Scientific (San Jose, CA) and had the following purities: >95%, >93%, and >90.1%, respectively.

    Published On: February 1st, 2008Categories: Citations, COVID-19, Dye-Labeled, FRET Substrates