Solid-phase peptide synthesis approaches require that the side chains of certain amino acids be protected from undesired reactivity during synthesis. The installation and removal of these protection groups results in a lower atom economy…

In this case study, we demonstrate the synthesis of a Goserelin peptide API impurity through a convergent peptide fragment strategy, expanding our approach to include the unprotected side chains of histidine, tryptophan, and arginine...

As a rapidly emerging class of next-generation drugs, stapled peptides are expected to combine the synthetic manipulability and cell-penetrating ability of small molecules with the three-dimensionality and versatile target recognition ability of biologics.

PEGylation is now a well-established technique in the field of targeted drug delivery systems. As more PEGylated therapeutic agents receive FDA approval, more attention has been given to site-specific PEGylation of discrete or monodispersed PEG chains.

Synthetic oligonucleotides constitute an important class of therapeutics developed to treat a variety of indications. Two main synthetic approaches exist for the conjugation of a peptide to an oligonucleotide: parallel and linear.

Electrospray ionization mass spectroscopy (ESI-MS) as a common technique for peptide characterization, but understanding and interpreting the spectrum can be complicated due to the multiplicity of the data.