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      1. Home
      2. Posts
      3. Metal Chelates

      Metal Chelates Archive

      • Sensitive Positron Emission Tomography Imaging of PD-L1 Expression in Human Breast and Lung Carcinoma Xenografts Using the Radiometalated Peptide Ga-68-TRAP-WL12.

        Quigley, Neil Gerard, Katja Steiger, Stefanie Felicitas Färber, Frauke Richter, Wilko Weichert, and Johannes Notni. Molecular Pharmaceutics (2024), 21(4), 1827-1837.

        … by positron emission tomography (PET) imaging and ex vivo … clinical PD-L1 PET imaging because it detects even very low … The peptide WL12 was purchased from CPC Scientific (San …

        Published On: February 5th, 2024Categories: Metal Chelates, Peptide Macrocycles, Unnatural Amino Acids
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      • An optimized radiosynthesis of [18F]DK222, a PET radiotracer for imaging PD‐L1.

        Holt, Daniel P., Dhiraj Kumar, Sridhar Nimmagadda, and Robert F. Dannals. Journal of Labelled Compounds and Radiopharmaceuticals 66, no. 2 (2023): 47-54.

        to current Good Manufacturing Practice (cGMP) requirements. In addition, the production is … -NODA; Figure 1) was custom synthesized from CPC Scientific (San Jose, CA). The authentic …

        Published On: January 10th, 2023Categories: Citations, GMP Peptide Manufacturing, Metal Chelates
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      • Theranostic cobalt-55/58m for neurotensin receptor-mediated radiotherapy in vivo: A pilot study with dosimetry.

        Lin, Wilson, Eduardo Aluicio-Sarduy, Hailey A. Houson, Todd E. Barnhart, Volkan Tekin, Justin J. Jeffery, Ashley M. Weichmann, Kendall E. Barrett, Suzanne E. Lapi, and Jonathan W. Engle. Nuclear Medicine and Biology) 118 (2023): 108329.

        Lyophilized NOTA-NT-20.3 (Ac-Lys(NOTA)-Pro-NMeArg-Arg-Pro-Tyr-Tle-Leu, 1383.6 g/mol, “NT”, CPC Scientific) was diluted to 1 mg/mL in ultrapure water (Milli-Q, >18.2 MΩ-cm) and used without further purification.

        Published On: January 2nd, 2023Categories: Citations, Metal Chelates, Unnatural Amino Acids
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      • Development and Preclinical Evaluation of 99m Tc-and 186 Re-Labeled NOTA and NODAGA Bioconjugates Demonstrating Matched Pair Targeting of GRPR-Expressing Tumors.

        Makris, G.; Bandari, R. P.; Kuchuk, M.; Jurisson, S. S.; Smith, C. J.; Hennkens, H. M., Molecular Imaging and Biology, 2021, 23 (1), 52-61.

        "NOTA/NODAGA-6Ahx- DPhe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 ; NOTA: 2,2′,2″-(1,4,7-triazacyclononane-1,4,7-triyl)triacetic acid and NODAGA: 2-(4,7-bis( carboxymethyl)-1,4,7-triazonan-1-yl)pentanedioic acid] were purchased from CPC Scientific [..]"

        Published On: September 4th, 2020Categories: Citations, Metal Chelates, Unnatural Amino Acids
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      • Granzyme B PET Imaging of the Innate Immune Response.

        Capaccione, Kathleen M., Mikhail Doubrovin, Nikunj Bhatt, Akiva Mintz, and Andrei Molotkov. Molecules 25, no. 13 (2020): 3102.

        NOTA–β-Ala–Gly–Gly–Ile–Glu–Phe–Asp–CHO (NOTA-GZP) was purchased from CPC scientific, Sunnyvale, CA, USA.

        Published On: May 20th, 2020Categories: Citations, Metal Chelates, Unnatural Amino Acids
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      • Development of [18F] FPy-WL12 as a PD-L1 specific PET imaging peptide.

        Lesniak, W. G.; Mease, R. C.; Chatterjee, S.; Kumar, D.; Lisok, A.; Wharram, B.; Kalagadda, V. R.; Emens, L. A.; Pomper, M. G.; Nimmagadda, S., Molecular Imaging 2019, 18, 1536012119852189.

        The PD-L1-binding peptide, WL12 (sequence shown in Figure 1A), was custom synthesized by CPC Scientific (Sunnyvale, California) with >95% purity.

        Published On: June 12th, 2019Categories: Citations, Metal Chelates, Peptide Macrocycles, Showcase Peptide Chelates, Unnatural Amino Acids
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      • IL13RA2 targeted alpha particle therapy against glioblastomas.

        Sattiraju, A., et al. Oncotarget 2017, 8 (26), 42997-43007.

        For Ac-225 labeling, the prepared DOTA-Pep-1L (CPC-scientific, San Jose, CA) was incubated with Ac-225 at 70°C for 50 minutes. The TLC plates were scanned on a BioScan Imaging Scanner. Cu-64 was purchased from Washington University in St. Louis. The custom peptide specific to IL13RA2 and a scrambled peptide were conjugated with NOTA by CPC scientific Inc (San Jose, CA). Both the peptides, Pep-1L and scrambled peptide-NOTA were radiolabeled with Cu-64 according to the previously reported methods [15].

        Published On: June 3rd, 2017Categories: Citations, Metal Chelates, Showcase Peptide Chelates
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      • Development of a radiolabeled irreversible peptide ligand for PET imaging of vascular endothelial growth factor.

        Marquez, B. V., et al. J Nucl Med 2014, 55 (6), 1029-34.

        "L19K was synthesized by CPC Scientific and comprised the sequence NO2A-PEG4-GGNECDIARMWEWECFERK-CONH2, with Cys-Cys disulfide bridge and polyethylene glycol (PEG4) as a spacer between peptide and chelator. "

        Published On: May 1st, 2017Categories: Citations, Metal Chelates, PEGylation, Showcase Peptide Chelates
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      • PET-based Imaging of Chemokine Receptor 2 in Experimental and Disease-related Lung Inflammation.

        Liu, Yongjian, et al. Radiology (2017): 161409.

        "Synthesis, Labeling, and Stability of ECL1i. The ECL1i peptide (LGTFLKC) was synthesized from d-form amino acids by CPC Scientific (Sunnyvale, Calif)."

        Published On: January 3rd, 2017Categories: Citations, D-Amino Acids, Metal Chelates
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      • Identification of a novel BODIPY minihepcidin tool for the high content analysis of Ferroportin (SLC40A1) pharmacology.

        Skerratt, Sarah E., Sian Humphreys, Rita Ferreira, Csilla Jorgensen, Joe Warmus, Lei Zhao, Xiaohe Tong, and Sarah A. Nickolls. MedChemComm 7, no. 8 (2016): 1564-1571.

        1. Pfizer Neusentis, The Portway Building, Granta Park, Cambridge, UK.
        2. Pfizer Worldwide Research & Development, Eastern Point Road, Groton, Connecticut 06340, USA.
        3. CPC Scientific Inc., 1245 Reamwood Avenue, Sunnyvale, CA 94089, USA.

        "antipeptide (EGVYVHPV), angiotensin II, human (DRVYIHPF), and isotopically (13C) labeled heptapeptide (AAAAHAA-NH2 [where “A” indicates a carbon thirteen (13C) "Synthesis was conducted at CPC Scientific Inc. Ac-Asp(OtBu)-Thr(tBu)-His(Trt)-Phe-Pro-Ile-Cys(Trt)-Ile-PhePEG3-Arg(Pbf)-Arg(Pbf)-Lys(Boc)-wang resin (2).. Ac-Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-PEG3-Arg-Arg-Lys(BODIPY_TMR_C6)."

        Published On: August 1st, 2016Categories: Citations, coauthored, Metal Chelates, PEGylation, publications
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      12Next
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