Nakagawa, Mayumi. U.S. Patent Application No. 14/566,604, filed August 13, 2015.
“To define the minimal and optimal amino acids sequences of the CD8 T-cell epitope, 8-mer, 10-mer, 11-mer, and homologous peptides were synthesized (CPC Scientific, Inc, San Jose, Calif.)… Their safety for human use is ensured, in accordance with FDA requirements…(each peptide to be assessed individually as per the FDA). ”
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Chen, Long, et al. Scientific Reports 6 (2016).
- Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, Peking University, Beijing 100871, China
- Department of Global Biotherapeutics Technologies, Pfizer Inc., Cambridge, MA 02140, USA
- School of Life Sciences, Nanjing University, China
- Peking-Tsinghua Center for Life Sciences, Beijing, China
"The Biotin-C6-LELPETGG-NH2, GGGY-Lys(Biotin)-NH2, and GGG-Lys(N3)-NH2 reagents were synthesized by CPC Scientific."
August 18th, 2016Citations, Click Peptides, Unnatural Amino AcidsGoupil, Louise S., et al. PLoS Negl Trop Dis 10.8 (2016): e0004893.
"Protease activity in regurgitant from three replicate tanks were compared using a mixture of 7 internally quenched fluorescent substrates available from CPC Scientific, Sunnyvale, California (Table 1) [AMYD-112, AMYD-114, AMYD-109, MMPS-024, SUBS-017, AMYD-111, CASP-060]. These substrates were chosen based on their diverse sequence composition to enable detection of multiple protease classes."
August 8th, 2016Citations, FRET SubstratesGarner, Thomas P., et al. Molecular Cell 63.3 (2016): 485-497.
"Hydrocarbon-stapled peptide corresponding to the BH3 domain of BIM, BIM SAHBA: N-acetylated 145EIWIAQELRS5IGDS5FNAYYA164-CONH2, where S5 represents the non-natural amino acid inserted for olefin metathesis, was synthesized, purified and characterized as previously described by CPC Scientific (Gavathiotis et al., 2008)."
August 4th, 2016Citations, Stapled PeptidesKarlsson, Erik A., et al. mBio 7.4 (2016): e01144-16.
"Peptides 20 amino acids in length spanning the HA and NA proteins of the A/Anhui/1/2013 (H7N9) virus were generated with 15-amino-acid overlaps, resulting in the synthesis of 110 HA peptides and 90 NA peptides synthesized at >90% purity (CPC Scientific). A small number of peptides were synthesized at >70% purity, following multiple synthesis and purification attempts. A poly(K) linker was added to each peptide to increase solubility and to improve the binding orientation of peptides to the Hydrogel slides."
August 2nd, 2016Citations, Peptide LibrariesSkerratt, Sarah E., Sian Humphreys, Rita Ferreira, Csilla Jorgensen, Joe Warmus, Lei Zhao, Xiaohe Tong, and Sarah A. Nickolls. MedChemComm 7, no. 8 (2016): 1564-1571.
- Pfizer Neusentis, The Portway Building, Granta Park, Cambridge, UK.
- Pfizer Worldwide Research & Development, Eastern Point Road, Groton, Connecticut 06340, USA.
- CPC Scientific Inc., 1245 Reamwood Avenue, Sunnyvale, CA 94089, USA.
"antipeptide (EGVYVHPV), angiotensin II, human (DRVYIHPF), and isotopically (13C) labeled heptapeptide (AAAAHAA-NH2 [where “A” indicates a carbon thirteen (13C) "Synthesis was conducted at CPC Scientific Inc. Ac-Asp(OtBu)-Thr(tBu)-His(Trt)-Phe-Pro-Ile-Cys(Trt)-Ile-PhePEG3-Arg(Pbf)-Arg(Pbf)-Lys(Boc)-wang resin (2).. Ac-Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-PEG3-Arg-Arg-Lys(BODIPY_TMR_C6)."
August 1st, 2016Citations, coauthored, Metal Chelates, PEGylation, publicationsFumakia, M. MS Thesis, University of Manitoba 2016.
LL37 (host defense peptide) (Table 2) was a purchased from (custom synthesized by CPC Scientific Inc., CA, USA)
July 22nd, 2016Antimicrobial Peptides, Citations, Cosmetic PeptidesKwon, Ester J., Matthew Skalak, Riana Lo Bu, and Sangeeta N. Bhatia. ACS Nano 10, no. 8 (2016): 7926-7933.
"[The peptides] were synthesized by CPC Scientific with N-terminal myristic acid."
July 18th, 2016Citations, LipidationChappell, D.L., Lee, A.Y., Bernstein, H.S., Lassman, M.E. and Laterza, O.F. Bioanalysis 8, no. 22 (2016): 2341-2349.
- Merck & Co., Inc. Rahway, NJ07065, USA
July 15th, 2016CitationsShcherbatko, Anatoly, Andrea Rossi, Davide Foletti, Guoyun Zhu, Oren Bogin, Meritxell Galindo Casas, Mathias Rickert et al. Journal of Biological Chemistry 291, no. 27 (2016): 13974-13986.
- Rinat Laboratories, Pfizer Inc., South San Francisco, California 94080
Large scale preparations were performed based on the described protocol by CPC Scientific.
July 1st, 2016Citations
