Nakagawa, Mayumi. U.S. Patent Application No. 14/566,604, filed August 13, 2015.
“To define the minimal and optimal amino acids sequences of the CD8 T-cell epitope, 8-mer, 10-mer, 11-mer, and homologous peptides were synthesized (CPC Scientific, Inc, San Jose, Calif.)… Their safety for human use is ensured, in accordance with FDA requirements…(each peptide to be assessed individually as per the FDA). ”
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Pandya, P., Sayers, R.O., Ting, J.P., Morshedian, S., Torres, C., Cudal, J.S., Zhang, K., Fitchett, J.R., Zhang, Q., Zhang, F.F. and Wang, J. PLoS One 15, no. 6 (2020): e0233961.
- Departments of Protein Engineering, Eli Lilly Biotechnology Center, Discovery Chemistry Research and Technologies, San Diego, California, United States of America
- Departments of Structural Biology, Quantitative Biology, and Recombinant Protein Generation, Discovery Chemistry Research and Technologies, and, Eli Lilly and Company, Indianapolis, Indiana, United States of America
- Centro de Investigacio´n Lilly, Alcobendas, Spain
Peptide synthesis was outsourced to CPC Scientific.
Mutations to the RBD of SARS-CoV have resulted in the reorganization of SARS-CoV-2 RBD, specifically to the loops that are in close proximity to the ACE2-binding ridge. Due to these structural changes, an additional intramolecular main-chain hydrogen bond is gained between Asn487 and Ala475 (Figure 4a). The Asn487–Ala475 hydrogen bond causes the RBM of SARS-CoV-2 to be more structurally compact, enabling the loop containing Ala475 to move into closer proximity to the ACE2 α1 helix. Closer contact between the RBM and α1 helix of ACE2 results in more intermolecular interactions (Figure 4a,b). Some of these interactions include hydrogen bonds between Gln493 (SARS-CoV-2) and Glu35 (ACE2),[3b,c] and main-chain hydrogen bonds between Gly502 and Lys31.
Froning, K., Maguire, J., Sereno, A., Huang, F., Chang, S., Weichert, K., Frommelt, A.J., Dong, J., Wu, X., Austin, H. and Conner, E.M. Nature Communications 11, no. 1 (2020): 2330.
- Eli Lilly Biotechnology Center, 10300 Campus Point Drive, San Diego, CA 92121, USA
SLLMWITQC (NY-ESO-1) peptide (synthesized by CPC Scientific), 100 μL total volume, for 3 h.
Buss, Colin G., and Sangeeta N. Bhatia. Proceedings of the National Academy of Sciences (2020).
Tandem Peptides. Tandem peptides were purchased from CPC Scientific. Sequences are: mTP-TAMRA-LyP1 (Myr-GWTLNSAGYLLGKINLKALA-ALAKKILGGGGK(5TAMRA)-CGNKRTRGC (C-C bridge)); [..] PEGylated formulations of these peptides were synthesized as previously described (49). The sequences are: [..] mTP-PEG-ARAL (Myr-GWTLNSAGYLLGKINLKALA-ALAKKILC-PEG5K-GGGARALPSQRSR).
To Our Valued Customers,
With the growing concern of the Coronavirus Disease 2019 (COVID-19) outbreak, CPC Scientific wants to assure you that our peptide manufacturing facilities are fully operational and staffed. We continue to deliver our GMP- and research-grade peptides on time to the researchers and pharmaceutical companies who rely on our products. The safety of […]
San Jose, CA and New York, NY – CPC Scientific Inc., a CDMO specializing in synthetic peptide manufacturing, will host at DCAT Week® for a 5th consecutive year. Their representatives will be open for meetings during March 23-26th at:
Omni Berkshire Place #1632
21 East 52nd St.
New York, NY 10022Appointments requests may be requested at the CPC […]
Kudryashev, Julia A., Lauren E. Waggoner, Hope T. Leng, Nicholas H. Mininni, and Ester J. Kwon. ACS Sensors (2020).
Calpain substrate peptide (QSY21-QEVYGAMP-K(Cy5)-PEG2-GC- NH2) was synthesized by CPC Scientific Inc. (Sunnyvale, CA …
Adem, Sandeep, Sonal Jain, Michael Sveiven, Xiahan Zhou, Anthony J. O’Donoghue, and Drew A. Hall. Scientific Reports 10, no. 1 (2020): 1-10
Biotin-PEG36-Thr-Phe-Ser-Tyr-Nle-Arg-Trp-Pro-PEG12-Cys (known as peptide) was synthesized by CPC Scientific..
