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      1. Home
      2. Posts
      3. Unnatural Amino Acids

      Unnatural Amino Acids Archive

      • Development and Preclinical Evaluation of 99m Tc-and 186 Re-Labeled NOTA and NODAGA Bioconjugates Demonstrating Matched Pair Targeting of GRPR-Expressing Tumors.

        Makris, G.; Bandari, R. P.; Kuchuk, M.; Jurisson, S. S.; Smith, C. J.; Hennkens, H. M., Molecular Imaging and Biology, 2021, 23 (1), 52-61.

        "NOTA/NODAGA-6Ahx- DPhe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 ; NOTA: 2,2′,2″-(1,4,7-triazacyclononane-1,4,7-triyl)triacetic acid and NODAGA: 2-(4,7-bis( carboxymethyl)-1,4,7-triazonan-1-yl)pentanedioic acid] were purchased from CPC Scientific [..]"

        Published On: September 4th, 2020Categories: Citations, Metal Chelates, Unnatural Amino Acids
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      • Engineering synthetic breath biomarkers for respiratory disease.

        Chan, Leslie W., Melodi N. Anahtar, Ta-Hsuan Ong, Kelsey E. Hern, Roderick R. Kunz, and Sangeeta N. Bhatia. Nature Nanotechnology (2020): 1-9.

        HFA-modifed peptides were synthesized by CPC Scientifc (>95% purity). Briefy, the peptide substrate, Ac-CKKK(Cy5)-PEG4-Nle(O-Bzl)-Met(O)2-Oic-Abu-OH, was synthesized on Fmoc-Abu-CTC resin via standard Fmoc solid phase peptide synthesis.

        Published On: July 20th, 2020Categories: Citations, Dye-Labeled, PEGylation, Unnatural Amino Acids
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      • CRISPR-Cas-amplified urine biomarkers for multiplexed and portable cancer diagnostics.

        Hao, Liangliang, Renee T. Zhao, Chayanon Ngambenjawong, Heather E. Fleming, and Sangeeta Bhatia. bioRxiv (2020).

        All peptides were chemically synthesized by CPC Scientific, Inc. [..] K(N3)-ANP-GPVPLSLVMGGC [..] 5FAM-GGf-Pip-KSGGGK(CPQ2)-PEG2-GC

        Published On: June 18th, 2020Categories: Citations, Click Peptides, Dye-Labeled, FRET Substrates, PEGylation, Unnatural Amino Acids
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      • Granzyme B PET Imaging of the Innate Immune Response.

        Capaccione, Kathleen M., Mikhail Doubrovin, Nikunj Bhatt, Akiva Mintz, and Andrei Molotkov. Molecules 25, no. 13 (2020): 3102.

        NOTA–β-Ala–Gly–Gly–Ile–Glu–Phe–Asp–CHO (NOTA-GZP) was purchased from CPC scientific, Sunnyvale, CA, USA.

        Published On: May 20th, 2020Categories: Citations, Metal Chelates, Unnatural Amino Acids
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      • CXCR4-binding PET tracers link monocyte recruitment and endothelial injury in murine atherosclerosis.

        Baba, Osamu, Andrew Elvington, Martyna Szpakowska, Deborah Sultan, Gyu Seong Heo, Xiaohui Zhang, Hannah Luehmann et al. bioRxiv (2020).

        The FC131 peptide (cyclo[2-Nal-Gly-d-Tyr-NMe-d-Orn-Arg]) was synthesized by CPC Scientific (Sunnyvale, CA).

        Published On: January 2nd, 2020Categories: Citations, D-Amino Acids, Peptide Macrocycles, Unnatural Amino Acids
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      • Single-cell assays using integrated continuous-flow microfluidics.

        Ng, Ee Xien, Myat Noe Hsu, Guoyun Sun, and Chia-Hung Chen. Methods in Enzymology 628 (2019): 59-94.

        The peptide sequences of the four FRET-based substrates ([..] CPC Scientific) are as follows: UV: AlexaFluor405-Leu-Ala-Gln-Ala-HompheArg-Ser-Lys (QSY35)-NH2; Blue: Dabcyl-Gly-Pro-Leu-Gly-Met-Arg-Gly-Lys (5-FAM)-NH2; Green: QSY7-Ala-Pro-Phe-Glu..

        Published On: October 31st, 2019Categories: Citations, Dye-Labeled, FRET Substrates, Unnatural Amino Acids
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      • Development of [18F] FPy-WL12 as a PD-L1 specific PET imaging peptide.

        Lesniak, W. G.; Mease, R. C.; Chatterjee, S.; Kumar, D.; Lisok, A.; Wharram, B.; Kalagadda, V. R.; Emens, L. A.; Pomper, M. G.; Nimmagadda, S., Molecular Imaging 2019, 18, 1536012119852189.

        The PD-L1-binding peptide, WL12 (sequence shown in Figure 1A), was custom synthesized by CPC Scientific (Sunnyvale, California) with >95% purity.

        Published On: June 12th, 2019Categories: Citations, Metal Chelates, Peptide Macrocycles, Showcase Peptide Chelates, Unnatural Amino Acids
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      • Extended intravitreal rabbit eye residence of nanoparticles conjugated with cationic arginine peptides for intraocular drug delivery: in vivo imaging.

        Melgar-Asensio, Ignacio, et al. Investigative Ophthalmology & Visual Science 59.10 (2018): 4071-4081.

        Thio-peptide: NH2-Cys-PEG4-Sar-YNLYRVRS-NH2, MW 1,490 g/mol was custom synthesized, via solid state methods by CPC Scientific (Sunnyvale, CA, USA).

        Published On: August 1st, 2018Categories: Citations, PEGylation, Unnatural Amino Acids
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      • A GLP-1:CCK fusion peptide harnesses the synergistic effects on metabolism of CCK-1 and GLP-1 receptor agonism in mice

        Hornigold, D.C., Roth, E., Howard, V., Will, S., Oldham, S., Coghlan, M.P., Blouet, C. and Trevaskis, J.L. Appetite 127 (2018): 334-340.

        1. Cardiovascular and Metabolic Diseases, MedImmune Ltd, Milstein Building, Granta Park, Cambridge, CB21 6GH, UK
        2. University of Cambridge, Department of Clinical Biochemistry, MRC Metabolic Diseases Unit, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK
        3. Cardiovascular and Metabolic Diseases, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA

        AC3174 (Amylin Pharmaceuticals) is a functional analog of exenatide (Hargrove et al., 2007). AC170222 (Hpa-Nle-Gly-Trp-Lys(Tac)-Asp-NMePhe-NH2; CPC Scientific, Sunnyvale, CA) is a CCKR1-selective peptide (Pierson et al., 2000).

        Published On: May 19th, 2018Categories: Citations, Unnatural Amino Acids
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      • IIsolation of an insulin-like peptide from the Asian malaria mosquito, Anopheles stephensi, that acts as a steroidogenic gonadotropin across diverse mosquito taxa.

        Nuss, Andrew B., and Mark R. Brown. General and Comparative Endocrinology (2017).

        "A bioactive form of AaILP3 (norLeu substituted for Met) was synthesized in the laboratory (Brown et al., 2008) and later by CPC Scientific, Inc. (Sunnyvale, CA). [..] stephensi ILP3 and ILP4 (CPC Scientific, Inc.)"

        Published On: March 1st, 2018Categories: Citations, Unnatural Amino Acids
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