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      1. Home
      2. Posts
      3. PEGylation

      PEGylation Archive

      • An Activity-Based Nanosensor for Traumatic Brain Injury

        Kudryashev, Julia A., Lauren E. Waggoner, Hope T. Leng, Nicholas H. Mininni, and Ester J. Kwon. ACS Sensors (2020).

        Calpain substrate peptide (QSY21-QEVYGAMP-K(Cy5)-PEG2-GC- NH2) was synthesized by CPC Scientific Inc. (Sunnyvale, CA …

        Published On: February 26th, 2020Categories: Citations, Dye-Labeled, FRET Substrates, PEGylation
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      • Giant magnetoresistive biosensors for real-time quantitative detection of protease activity.

        Adem, Sandeep, Sonal Jain, Michael Sveiven, Xiahan Zhou, Anthony J. O’Donoghue, and Drew A. Hall. Scientific Reports 10, no. 1 (2020): 1-10

        Biotin-PEG36-Thr-Phe-Ser-Tyr-Nle-Arg-Trp-Pro-PEG12-Cys (known as peptide) was synthesized by CPC Scientific..

        Published On: January 27th, 2020Categories: Citations, PEGylation, Showcase PEGylation
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      • Extended intravitreal rabbit eye residence of nanoparticles conjugated with cationic arginine peptides for intraocular drug delivery: in vivo imaging.

        Melgar-Asensio, Ignacio, et al. Investigative Ophthalmology & Visual Science 59.10 (2018): 4071-4081.

        Thio-peptide: NH2-Cys-PEG4-Sar-YNLYRVRS-NH2, MW 1,490 g/mol was custom synthesized, via solid state methods by CPC Scientific (Sunnyvale, CA, USA).

        Published On: August 1st, 2018Categories: Citations, PEGylation, Unnatural Amino Acids
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      • Development of a radiolabeled irreversible peptide ligand for PET imaging of vascular endothelial growth factor.

        Marquez, B. V., et al. J Nucl Med 2014, 55 (6), 1029-34.

        "L19K was synthesized by CPC Scientific and comprised the sequence NO2A-PEG4-GGNECDIARMWEWECFERK-CONH2, with Cys-Cys disulfide bridge and polyethylene glycol (PEG4) as a spacer between peptide and chelator. "

        Published On: May 1st, 2017Categories: Citations, Metal Chelates, PEGylation, Showcase Peptide Chelates
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      • Ultrasensitive tumor-penetrating nanosensors of protease activity.

        Kwon, Ester J., Jaideep S. Dudani, and Sangeeta N. Bhatia. Nature Biomedical Engineering 1 (2017): 0054.

        [..] MMP substrate, 5-FAM–GGPLGVRGKK(CPQ2)–PEG2–C; thrombin substrate, 5-FAM–GGfPRSGGGK(CPQ2)–PEG2–C; where 5-FAM is the 5-carboxyfluorescein fluorophore, CPQ2 is the quencher, PEG2 is the linker polyethylene glycol, [..] dye for urinary detection (biotin–CGPLGVRGKK(Cy7)eGvndneeGffsar; Cy7 is cyanine7). Targeting peptides were [..] cyclized: LyP1, C–K(5-FAM)–C6–CGNKRTRGC; iRGD, C–PEG2–CRGDKGPDC; where C6 is the 6-aminohexanoic acid linker [..]

        Published On: April 10th, 2017Categories: Citations, Dye-Labeled, FRET Substrates, PEGylation, Showcase FRET Peptides
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      • Novel theranostic nanoporphyrins for photodynamic diagnosis and trimodal therapy for bladder cancer.

        Lin, Tzu-Yin, et al. Biomaterials 104 (2016): 339-351.

        "Our previously reported PLZ4-PEG 5k -CA 8 telodendrimer was synthesized by the conjugation of alkyne-derivatized bladder cancer targeting ligand PLZ4 (CPC Scientific, Sunnyvale, CA)"

        Published On: October 1st, 2016Categories: Citations, Click Peptides, PEGylation
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      • Identification of a novel BODIPY minihepcidin tool for the high content analysis of Ferroportin (SLC40A1) pharmacology.

        Skerratt, Sarah E., Sian Humphreys, Rita Ferreira, Csilla Jorgensen, Joe Warmus, Lei Zhao, Xiaohe Tong, and Sarah A. Nickolls. MedChemComm 7, no. 8 (2016): 1564-1571.

        1. Pfizer Neusentis, The Portway Building, Granta Park, Cambridge, UK.
        2. Pfizer Worldwide Research & Development, Eastern Point Road, Groton, Connecticut 06340, USA.
        3. CPC Scientific Inc., 1245 Reamwood Avenue, Sunnyvale, CA 94089, USA.

        "antipeptide (EGVYVHPV), angiotensin II, human (DRVYIHPF), and isotopically (13C) labeled heptapeptide (AAAAHAA-NH2 [where “A” indicates a carbon thirteen (13C) "Synthesis was conducted at CPC Scientific Inc. Ac-Asp(OtBu)-Thr(tBu)-His(Trt)-Phe-Pro-Ile-Cys(Trt)-Ile-PhePEG3-Arg(Pbf)-Arg(Pbf)-Lys(Boc)-wang resin (2).. Ac-Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-PEG3-Arg-Arg-Lys(BODIPY_TMR_C6)."

        Published On: August 1st, 2016Categories: Citations, coauthored, Metal Chelates, PEGylation, publications
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      • Photoactivated Spatiotemporally-Responsive Nanosensors of in Vivo Protease Activity.

        Dudani, Jaideep S., et al. ACS Nano 9.12 (2015): 11708-11717.

        "...protease activity are focused on functionalizing synthetic peptide substrates with reporters that emit ... In vivo, veiled nanosensors are selectively activated at the ..... sized by CPC Scientific, Inc. (V1: Biotin-PEG(5 kDa)-(KFAM)-..."

        Published On: November 13th, 2015Categories: Citations, Dye-Labeled, PEGylation
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      • Cyclotron Production of High–Specific Activity 55 Co and In Vivo Evaluation of the Stability of 55 Co Metal-Chelate-Peptide Complexes.

        Mastren, Tara, et al. Molecular Imaging 14.10 (2015): 11-22.

        "Two versions of the peptide L19K were synthesized by CPC Scientific (Sunnyvale, CA) consisting of the sequence DO3A- or NO2A-PEG4-GGNECDIARMWEWECFERK-CONH2, with a Cys-Cys disulfide bridge and polyethylene glycol (PEG) as a spacer between peptide and chelate."

        Published On: October 1st, 2015Categories: Citations, Metal Chelates, PEGylation
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      • Mathematical framework for activity-based cancer biomarkers.

        Kwong, Gabriel A., et al. Proceedings of the National Academy of Sciences 112.41 (2015): 12627-12632.

        "Cysteine-terminated peptides (Q1 = 5FAM-GGPLGVRGKK(CPQ-2)-PEG2-C, CPC Scientific.."

        Published On: September 28th, 2015Categories: Citations, Dye-Labeled, FRET Substrates, PEGylation
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