This white paper demonstrates how targeted green chemistry practices can be successfully integrated into large-scale SPPS. Our team has developed an innovative DMF recycling strategy that improves process sustainability and cost efficiency...

Mass spectroscopy-based techniques have evolved as a powerful tool in proteomics. Stable isotope-labeled peptides (SIL peptides) are chemically and physically indistinguishable from their endogenous counterparts with respect to retention time, ionization efficiency, and fragmentation pathways.

This white paper explores the click cyclization of RP-182, a promising cancer immunotherapy candidate. Our innovative approach showcases the use of copper catalysis to increase the macrocyclization efficiency of longer peptides under green reaction conditions.

As a rapidly emerging class of next-generation drugs, stapled peptides are expected to combine the synthetic manipulability and cell-penetrating ability of small molecules with the three-dimensionality and versatile target recognition ability of biologics.

In this case study, we demonstrate the synthesis of a Goserelin peptide API impurity through a convergent peptide fragment strategy, expanding our approach to include the unprotected side chains of histidine, tryptophan, and arginine...

Explore this case study on how our SPPS process optimizations have enabled multi-kilo delivery of a pharmaceutically relevant decapeptide within a challenging timescale, while improving environmental impact and production costs...