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      1. Home
      2. Posts
      3. Peptide Macrocycles

      Peptide Macrocycles Archive

      • CXCR4-binding PET tracers link monocyte recruitment and endothelial injury in murine atherosclerosis.

        Baba, Osamu, Andrew Elvington, Martyna Szpakowska, Deborah Sultan, Gyu Seong Heo, Xiaohui Zhang, Hannah Luehmann et al. bioRxiv (2020).

        The FC131 peptide (cyclo[2-Nal-Gly-d-Tyr-NMe-d-Orn-Arg]) was synthesized by CPC Scientific (Sunnyvale, CA).

        Published On: January 2nd, 2020Categories: Citations, D-Amino Acids, Peptide Macrocycles, Unnatural Amino Acids
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      • A rationally designed humanized antibody selective for amyloid beta oligomers in Alzheimer’s disease.

        Gibbs, Ebrima, Judith M. Silverman, Beibei Zhao, Xubiao Peng, Jing Wang, Cheryl L. Wellington, Ian R. Mackenzie, Steven S. Plotkin, Johanne M. Kaplan, and Neil R. Cashman. Scientific Reports 9, no. 1 (2019): 1-14.

        The conformational epitope was synthesized as a cyclic peptide with additional N-terminal residues CG and a C-terminal G to recapitulate the predicted structure of HHQK on AβO. Peptide synthesis was performed by CPC Scientific Inc. (Sunnyvale CA, USA) [..] Cyclization was performed via a head-to-tail (C-G) amide bond and c[CGHHQKG] was then conjugated to either keyhole limpet hemocyanin (KLH) or bovine serum albumin (BSA) via maleimide-based coupling.

        Published On: July 8th, 2019Categories: Citations, Peptide Macrocycles
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      • Development of [18F] FPy-WL12 as a PD-L1 specific PET imaging peptide.

        Lesniak, W. G.; Mease, R. C.; Chatterjee, S.; Kumar, D.; Lisok, A.; Wharram, B.; Kalagadda, V. R.; Emens, L. A.; Pomper, M. G.; Nimmagadda, S., Molecular Imaging 2019, 18, 1536012119852189.

        The PD-L1-binding peptide, WL12 (sequence shown in Figure 1A), was custom synthesized by CPC Scientific (Sunnyvale, California) with >95% purity.

        Published On: June 12th, 2019Categories: Citations, Metal Chelates, Peptide Macrocycles, Showcase Peptide Chelates, Unnatural Amino Acids
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      • Rapid PD-L1 detection in tumors with PET using a highly specific peptide.

        Chatterjee, Samit, et al. Biochemical and Biophysical Research Communications 483.1 (2017): 258-263.

        PD-L1 binding peptide, WL12, was custom synthesized by CPC Scientific (Sunnyvale, CA) with >95% purity.

        Published On: January 29th, 2017Categories: Citations, Peptide Macrocycles, Showcase Macrocycles, Unnatural Amino Acids
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      • A comparison of modular PEG incorporation strategies for stabilization of peptide-siRNA nanocomplexes.

        Lo, Justin H., et al. Bioconjugate Chemistry (2016).

        "Myristoyl-transportan−LyP-1 tandem peptide was synthesized by CPC Scientific (sequence: myr-GGWTLNSAGYLLGKINLKALAALAKKIL-GGGG-CGNKRTRGC, Cys−Cys bridge). FAM-labeled LyP-1 bearing an azide (azidoacetyl-GGG-cyclo-(EGNKRTRGK)), FAM-labeled LyP-1 bearing a cysteine (C-K(5FAM)-C6-cyclo-(CGNKRTRGC)) and transportan bearing a C-terminal cysteine (myristic acid-GGWTLNSAGYLLGKINLKALAALAKKILC) were synthesized by CPC Scientific, Inc."

        Published On: September 1st, 2016Categories: Citations, Click Peptides, Dye-Labeled, Lipidation, Peptide Macrocycles
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      • Glucagon responses to exercise-induced hypoglycaemia are improved by somatostatin receptor type 2 antagonism in a rat model of diabetes.

        Leclair, E., Liggins, R.T., Peckett, A.J., Teich, T., Coy, D.H., Vranic, M. and Riddell, M.C. Diabetologia (2016): 1-8.

        "The SSTR2a (PRL-2903) was purchased by CPC Scientific (Sunnyvale, CA, USA) and the dose (10 mg/kg body mass) approximated that given in our prior studies [25–27]. The antagonist was dissolved in saline and given in a 2 ml/kg volume."

        Published On: April 13th, 2016Categories: Citations, Peptide Macrocycles, Showcase Unnatural Amino Acids, Unnatural Amino Acids
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      • Preliminary Therapy Evaluation of 225Ac-DOTA-c (RGDyK) Demonstrates that Cerenkov Radiation Derived from 225Ac Daughter Decay Can Be Detected by Optical Imaging for In Vivo Tumor Visualization.

        Pandya, Darpan N., et al. Theranostics 6.5 (2016): 698.

        DOTA-c(RGDyK) was purchased from CPC Scientific, Inc. (Sunnyvale, CA), and its purity and mass were confirmed at Wake Forest using HPLC and electrospray ionization (ESI) mass spectrometry as described below.

        Published On: March 2nd, 2016Categories: Citations, Metal Chelates, Peptide Macrocycles, Showcase Peptide Chelates
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      • Molecular imaging investigations of a 67Ga/64Cu labeled..ligand,[RGD-Glu-(DO3A)-6-Ahx-RM2], targeting GRPR/αvβ3 biomarkers.

        Jiang, Zongrun, et al. Radiochimica Acta 104.7 (2016): 499-512.

        "[RGD-Glu-(DO3A)-6-Ahx-RM2], [Cyclo-(Arg-Gly-Asp-D-Tyr- Lys)-(DO3A)-Glu-(6-Ahx-D-Phe-Gln-Trp-Ala-Val-Gly-His- Sta-Leu-NH2)], was purchased from CPC Scientific (Sunnyvale, CA, USA)."

        Published On: February 26th, 2016Categories: Citations, Metal Chelates, Peptide Macrocycles
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      • Radiolabeling and biological evaluation of the GX1 and RGD-GX1 peptide sequence for angiogenesis targeting.

        Oliveira, E. A., and B. L. Faintuch. Nuclear Medicine and Biology 42.2 (2015): 123-130.

        "...4 -c(GX1) 774.9 μM or HYNIC-E-[c(RGDfk)-c(GX1)] 569.5 μM (μg/mL) (CPC Scientific Inc., CA ... 5 /well) were seeded into well culture plates, and it was added the radiotracers 99m Tc-HYNIC-PEG 4 -c ... For nonspecific binding assays, cold conjugate (1 mmol/L/well) was also ..."

        Published On: September 28th, 2014Categories: Citations, Metal Chelates, PEGylation, Peptide Macrocycles
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      • Indium-111 labeled gold nanoparticles for in-vivo molecular targeting.

        Ng, Quinn KT, et al. Biomaterials 35.25 (2014): 7050-7057.

        "Linear and cyclic targeting sequences of the peptides CCVVVT-EG4-GRGDSP-NH2 (97%) (Cap-lRGD) and c[RGDfK(CCVVVT-EG 4 )] (96%) (Cap-cRGD) were purchased from CPC Scientific."

        Published On: August 1st, 2014Categories: Citations, Peptide Macrocycles
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