Description

Peptide that binds with high affinity to CRF receptor types 1, 2a & 2b, stimulates cAMP accumulation from cells transfected with those receptors, and acts in vitro to releaes ACTH from dispersed rat anterior pituitary cells. In using a genomic library, the human urocortin has been cloned and localized to human chromosome 2. It has also been discovered that both human and rat urocortin share 95% identity within the mature peptide region.

SEQUENCE: H-Asp-Asn-Pro-Ser-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2 (trifluoroacetate salt)

ONE-LETTER SEQUENCE: DNPSLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV-NH2

MOLECULAR FORMULA: C₂₀₄H₃₃₇N₆₃O₆₄

MOLECULAR WEIGHT: 4696.31

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [176591-49-4]

SYNONYMS:

RESEARCH AREA: Neuropeptides

REFERENCES:
C.J. Donaldson et al., Endocrinology, 137, 2167 (1996)

SKU(s): UROC-001A, UROC-001B

KEYWORDS: