Description

Reversible N-type Ca2+ Channel Blocker ω-Conotoxin MVIIA, originally isolated from the venom of the fish-hunting cone snail Conus magus, is a blocker of voltage-sensitve Ca2+ channels in neurons. It has been used to identify different Ca2+ channel subtypes in amphibian brain.

SEQUENCE: H-Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2 (acetate salt)
(Disulfide bridge: Cys1-Cys16, Cys8-Cys20, and Cys15-Cys25)

ONE-LETTER SEQUENCE: CKGKGAKCSRLMYDCCTGSCRSGKC-NH2 (Disulfide bridge: 1-16, 8-20, and 15-25)

MOLECULAR FORMULA: C₁₀₂H₁₇₂N₃₆O₃₂S₇

MOLECULAR WEIGHT: 2639.1

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [107452-89-1]

SYNONYMS: Ziconotide, SNX-111

RESEARCH AREA: Toxin

REFERENCES:
Olivera, BM. et al. Biochem. 26, 2086 (1987)
Hillyard, DR. et al. Neuron. 9, 69 (1992).)
B.M. Olivera, L.J. Cruz, V. de Santos, G.W. Le Cheminant, D. Griffin, R. Zeikus, J.M. McIntosh, R. Galyean, J. Varga, W.R. Gray, and J. Rivier, Biochemistry, 26, 2086 (1987). (Original)
K. Valentino, R. Newcomb, T. Gadbois, T. Singh, S. Bowersox, S. Binter, A. Justice, D. Yamashiro, B.B. Hoffman, R. Ciaranello, G. Miljanich, and J. Ramachandran, Proc. Natl. Acad. Sci. USA, 90, 7894 (1993). (Pharmacol.)
J.A. Fox, Pflügers Arch., 429, 873 (1995). (Pharmacol.)

SKU(s): TOXI-002A, TOXI-002B

KEYWORDS: