Description

This fluorogenic peptide substrate can be used to monitor 20S Immunoproteasome activity. The peptide is hydrolyzed by the Immunoproteasome ß1i/LMP2 subunit, but not effectively cleaved by constitutive 20S Proteasomes.

SEQUENCE: Ac-Pro-Ala-Leu-AMC

ONE-LETTER SEQUENCE: Ac-PAL-AMC

MOLECULAR FORMULA: C₂₆H₃₄N₄O₆

MOLECULAR WEIGHT: 498.57

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [1431362-79-6]

SYNONYMS: Acetyl-Pro-Ala-Leu-7-amino-4-Methylcoumarin, Ac-Pro-Ala-Leu-AMC

RESEARCH AREA: Protein Kinases and Phosphatases, Immunomodulation

CATEGORY: Substrate and Enzyme Inhibitors »

REFERENCES:
Xie, Y. J. Mol. Cell Biol. 2: 308 (2010)
Cascio, P. et al. EMBO J. 20: 2357 (2001)
Lee, W. & Kim, K.B. Curr. Top. Med. Chem. 11: 2923 (2011)

SKU(s): SUBS-053A, SUBS-053B, SUBS-053C, SUBS-053D

KEYWORDS: