Description

Crosstide is a peptide analog of glycogen synthase kinase-3 (GSK-3) that functions as a natural substrate for Akt/PKB and displays similar specificities towards PKBalpha, PKBbeta and PKB-gamma isoforms. It is also recognized by MAPKAP kinase-1 and p70S6K. The fluorescent and biotinlyated peptides demonstrate similar enzyme activities.

SEQUENCE: H-Gly-Arg-Pro-Arg-Thr-Ser-Ser-Phe-Ala-Glu-Gly-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: GRPRTSSFAEG

MOLECULAR FORMULA: C₄₈H₇₇N₁₇O₁₇

MOLECULAR WEIGHT: 1164.2

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [171783-05-4]

SYNONYMS:

RESEARCH AREA: Apoptosis

REFERENCES:
Dai, F. et al. Biochem. Biophys. Res. Commun. 293, 1191 (2002)
Meier, R. et al. J. Biol. Chem. 272, 30491 (1997)
Chan, TO. et al. Ann. Rev. Biochem. 68, 965 (1999)

SKU(s): SUBS-018A

KEYWORDS: