Description

This neuropeptide was found in the gut as well as in the brain. It is responsible for a number of excitatory effects on both central and peripheral neurons. It contracts smooth muscle, constricts bronchioles and increases capillary permeability. When released from afferent nerves, it causes a neurogenic inflammatory response, including mast cell degranulation.

SEQUENCE: H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (trifluoroacetate salt)

ONE-LETTER SEQUENCE: RPKPQQFFGLM-NH2

MOLECULAR FORMULA: C₆₃H₉₈N₁₈O₁₃S₁

MOLECULAR WEIGHT: 1347.7

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [33507-63-0]

SYNONYMS:

RESEARCH AREA: Neuropeptides, Pain, Inflammation, Hormonal

REFERENCES:
A.I. Roberts et al., Cell Immunol., 141, 457 (1992)

SKU(s): SUBS-001A, SUBS-001B, SUBS-001C

KEYWORDS: