Description

Tachykinin antagonist that is a more potent substance P antagonist than spantide I and less effective in releasing histamine from mast cells. It also displays negligible neurotoxicity when compared with spantide I.

SEQUENCE: H-DLys(Nicotinoyl)-Pro-(3-Pyridyl)Ala-Pro-(3,4-dichloro)DPhe-Asn-DTrp-Phe-DTrp-Leu-Nle-NH2 (trifluoroacetate salt)

ONE-LETTER SEQUENCE: DLys(Nicotinoyl)-P-(3-Pyridyl)Ala-P-(3,4-dichloro)DPhe-N-DTrp-F-DTrp-L-Nle-NH2

MOLECULAR FORMULA: ₈₆H₁₀₄N₁₈O₁₃Cl₂

MOLECULAR WEIGHT: 1668.79

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [129176-97-2]

SYNONYMS: (D-Lys(nicotinoyl)¹,β-(3-pyridyl)-Ala³,3,4-dichloro-D-Phe⁵,Asn⁶,D-Trp⁷·⁹,Nle¹¹)-Substance P, H-D-Lys(nicotinoyl)-Pro-β-(3-pyridyl)-Ala-Pro-3,4-dichloro-D-Phe-Asn-D-Trp-Phe-D-Trp-Leu-Nle-NH₂

RESEARCH AREA: Neuropeptides

REFERENCES:
Folkers et al., PNAS, 87, 4833 (1990)
R. Kakanson et al., BBRC, 178, 297 (1991)

SKU(s): SUBP-003A, SUBP-003B

KEYWORDS: hormone