Description

DOTA-conjugated somatostatin analog for labeling with radiometals such as gallium-67 or gallium-68, indiuM^-111, and yttrium-90. Potentially useful for receptor-mediated tumor imaging and peptide receptor-targeted radionuclide therapy.

SEQUENCE: 4,7,10-Tricarboxymethyl-1,4,7,10-tetraaza-cyclododecan-1-yl-acetyl-D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Cys-Thr-OH
(Disulfide bond)

ONE-LETTER SEQUENCE: DOTA-fCYwKTCT (Cys & Cys bridge)

MOLECULAR FORMULA: C₆₅H₉₀N₁₄O₁₉S₂

MOLECULAR WEIGHT: 1435.65

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [177943-89-4]

SYNONYMS: DOTA-(Tyr³)-Octreotate, DOTA-[Tyr3] Octreotide Acid (Octreotate), DOTATATE, DOTA-(Tyr³,Thr⁸)-Octreotide, DOTATATE

RESEARCH AREA: Gastrointestinal

REFERENCES:
W.A.Breeman et al., Eur. J. Nucl. Med. Mol. Imaging, 30, 917 (2003)
A.Capello et al., Cancer Biother. Radiopharm., 18, 761 (2003)
M.de Jong et al., J. Nucl. Med., 46, 13S (2005)
L.Kolby et al., Br. J. Cancer, 93, 1144 (2005)
R.Valkema et al., J. Nucl. Med., 46, 83S (2005)

SKU(s): SOMA-011A, SOMA-011B

KEYWORDS: hormone