Description

This peptide inhibits binding of one of formyl peptide receptor-like 1 (FPRL1) agonists WKYMVm to its specific receptor. FPRL1 is an important classical chemoattractant receptor that is expressed in phagocytic cells in the peripheral blood and brain. Activation of FPRL1 is closely related to inflammatory responses in the host defense mechanism and neurodegenerative disorders.

SEQUENCE: H-Trp-Arg-Trp-Trp-Trp-Trp-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: WRWWWW

MOLECULAR FORMULA: C₆₁H₆₄N₁₄O₇

MOLECULAR WEIGHT: 1105.3

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [878557-55-2]

SYNONYMS: WRW4, Formyl Peptide Receptor-Like 1 (FPRL1) Antagonist, H-Trp-Arg-Trp-Trp-Trp-Trp-OH

RESEARCH AREA: Inflammation

REFERENCES:
Bae, Y-S. et al. J. Immunol. 173, 607 (2004).
Stenfeldt, Anna-Lena, et al. Inflammation 30.6 (2007): 224-229.
Bj?rkman, Lena, et al. Journal of Leukocyte Biology 83.2 (2008): 245-253.
Lee, Ha Young, et al. The Journal of Immunology 181.6 (2008): 4332-4339.

SKU(s): SIGN-018A, SIGN-018B, SIGN-018C, SIGN-018D

KEYWORDS: