Description

This is amino acids 676 to 700 fragment of steroid receptor co-activator (SRC1). This N-terminnaly biotinylated peptide is derived from the second LXXLL motif of SRC1. Co-activator proteins interact with nuclear receptors in a ligand-dependent manner and augment transcription. A short amphipathic betalpha-Helical domain that includes this LXXLL motif serves as the interaction interface between the co-activator molecules and the ligand-dependent activation function (AF-2) located in the COOH-terminus of the nuclear receptor ligand-binding domain (LBD). Receptor binding domain of the co-activator SRC-1 is specifically recruited to the farnesoid X receptor (FXR) ligand-binding domain

SEQUENCE: Biotin-Cys-Pro-Ser-Ser-His-Ser-Ser-Leu-Thr-Glu-Arg-His-Lys-Ile-Leu-His-Arg-Leu-Leu-Gln-Glu-Gly-Ser-Pro-Ser-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: Biotin-CPSSHSSLTERHKILHRLLQEGSPS

MOLECULAR FORMULA: C₁₂₈H₂₀₉N₄₁O₄₀S₂

MOLECULAR WEIGHT: 3026.42

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER:

SYNONYMS:

RESEARCH AREA: Inflammation

REFERENCES:

SKU(s): SIGN-015A

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