Description

This is amino acids 796 to 815 fragment of the chicken gizzard smooth-muscle myosin light-chain kinase (smMLCKp or P7) peptide, calmodulin (CaM)-binding domain . It retains its affinity for CaM and represents an adequate model for a complex of CaM with intact smMLCK protein. In the globular (Ca2+)4-CaM-P7 complex, the protein is wrapped around the -helical peptide. All the lysine and arginine charges of P7 are in close contact with the negatively charged side chains of the acidic residues of CaM. Calmodulin operates as a Ca2+ sensor and is known to interact with and regulate hundreds of proteins involved in many aspects of cellular function.

SEQUENCE: H-Ala-Arg-Arg-Lys-Trp-Gln-Lys-Thr-Gly-His-Ala-Val-Arg-Ala-Ile-Gly-Arg-Leu-Ser-Ser-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: ARRKWQKTGHAVRAIGRLSS

MOLECULAR FORMULA: C₉₈H₁₆₈N₃₈O₂₅

MOLECULAR WEIGHT: 2278.7

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER:

SYNONYMS:

RESEARCH AREA: Protein Kinases and Phosphatases

REFERENCES:
Frederick, K. et al. Nature 448, 325 (2007)
André. I. et al. Biophys. J. 90, 2903 (2006)

SKU(s): SIGN-013A

KEYWORDS: