Description

This peptide is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epidermal maturation. Exposing submerged keratinocytes monolayers to JAG-1 with elevated calcium concentration produces stratification with loricrin expression and NF-?B activation.

SEQUENCE: H-Cys-Asp-Asp-Tyr-Tyr-Tyr-Gly-Phe-Gly-Cys-Asn-Lys-Phe-Cys-Arg-Pro-Arg-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: CDDYYYGFGCNKFCRPR

MOLECULAR FORMULA: C₉₃H₁₂₇N₂₅O₂₆S₃

MOLECULAR WEIGHT: 2107.4

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER:

SYNONYMS:

RESEARCH AREA: Protein Kinases and Phosphatases

REFERENCES:
Nickoloff, B. et al. Cell Death Different. 9, 842 (2002).

SKU(s): SIGN-009A

KEYWORDS: