Description

This tridecapeptide, an alpha-factor pheromone of Saccharomyces cerevisiae, induces conjugation in yeast by binding to Ste2p. Its cognate GPCR activates a G protein signal pathway that highly conserves with mammalian signaling pathways.

SEQUENCE: H-Trp-His-Trp-Leu-Gln-Leu-Lys-Pro-Gly-Gln-Pro-Met-Tyr-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: WHWLQLKPGQPMY

MOLECULAR FORMULA: C₈₂H₁₁₄N₂₀O₁₇S₁

MOLECULAR WEIGHT: 1684

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [59401-28-4]

SYNONYMS:

RESEARCH AREA: Hormonal

REFERENCES:

D.Stötzler et al., Eur. J. Biochem., 69, 397 (1976)
Y.Masui et al., Biochem. Biophys. Res. Commun., 78, 534 (1977)
E.Ciejek et al., Biochem. Biophys. Res. Commun., 78, 952 (1977)
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T.Tanaka and H.Kita, Biochem. Biophys. Res. Commun., 83, 1319 (1978)
Y.Masui et al., Biochem. Biophys. Res. Commun., 86, 982 (1979)
H.H.Liao and J.Thorner, Proc. Natl. Acad. Sci. USA, 77, 1898 (1980)
G.P.Samokhin et al., Exp. Cell Res., 131, 267 (1981)
D.B.Finkelstein and L.McAlister, J. Biol. Chem., 256, 2561 (1981)
O.Emter et al., Biochem. Biophys. Res. Commun., 116, 822 (1983)
F.Naider and J.M.Becker, CRC Crit. Rev. Biochem., 21, 225 (1986)
Lee, BK. et al. J. Biol. Chem. 276, 37950 (2001)
Mayrhofer, S. and S. Pöggeler Eukaryot. Cell 4, 661 (2005).

SKU(s): SIGN-001A, SIGN-001B

KEYWORDS: