Description

This peptide binds specifically and with high affinity to alphavbeta3 receptors on neovascular blood vessel sections of different major human cancers. The integrin alpha(IIb)beta(3)-specific cyclic hexapeptide contains an Arg-Gly-Asp (RGD) sequence.

SEQUENCE: Cyclo[RGD-DPhe-Lys(Azido-PEG4)]

ONE-LETTER SEQUENCE: Cyclo (-RGDfK)(Azido_PEG4))

MOLECULAR FORMULA: C₃₈H₆₀N₁₂O₁₂

MOLECULAR WEIGHT: 876.96

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER:

SYNONYMS:

RESEARCH AREA: Cancer

REFERENCES:
Van Hagen, PM. et al. Int. J. Cancer 90, 186 (2000)
Hu, B. et al. Biochem. 39, 2284 (2000)

SKU(s): RGDP-011A

KEYWORDS: lactam, peptide macrocycle