Description

This peptide is derived from residues 14-21 of protein kinase C C2 (epsilonPKC C2). This peptide specifically inhibits epsilon-PKC by disrupting PKC binding to its receptor, RACK2. epsilonPKC mediated signal transduction plays a role in cell proliferation, differentiation, and apoptosis.

SEQUENCE: H-Glu-Ala-Val-Ser-Leu-Lys-Pro-Thr-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: EAVSLKPT

MOLECULAR FORMULA: C₃₇H₆₅N₉O₁₃

MOLECULAR WEIGHT: 844.0

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [182683-50-7]

SYNONYMS: PKCε Inhibitor Peptide

RESEARCH AREA: Protein Kinases and Phosphatases

REFERENCES:
Lamy, C. et al. Tetrahedron Lett. 46, 6177 (2007)
Brandman, R. et al. J. Biol. Chem. 282, 4113 (2007)

SKU(s): PPEP-004A

KEYWORDS: