Description

CKS-17 is a heptadecapeptide isolated from a highly conserved region of the immunosuppressive retroviral envelope protein p15E that is also capable of inhibiting lymphocyte proliferation, B cell activation, natural killer cell cytotoxicity, and monocyte-mediated tumor cytotoxicity. It has been found that CKs-17 leads to the rise of intracellular cAMP levels that may affect several physiological cellular functions.

SEQUENCE: H-Leu-Gln-Asn-Arg-Arg-Gly-Leu-Asp-Leu-Leu-Phe-Leu-Lys-Glu-Gly-Gly-Leu-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: LQNRRGLDLLFLKEGGL

MOLECULAR FORMULA: C₈₇H₁₄₈N₂₆O₂₄

MOLECULAR WEIGHT: 1942.29

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [99273-04-8]

SYNONYMS:

RESEARCH AREA: Antimicrobial, Antiviral

REFERENCES:
Nelson M, Nelson DS, Cianciolo GJ, Snyderman R. Cancer Immunol Immunother. 30(2), 113-118, (1989)
R. A. J. Oostendorp et al., Eur. J. Immunol., 22, 1505 (1992)

SKU(s): PKCP-012A

KEYWORDS: