Description

This peptide is the fragment 42-47 of the thrombin receptor, which acts as a thrombin receptor activator. It is effective in causing tyrosine phosphorylation, inhibition of cAMP formation, and an increase in cytosolic Ca2+.

SEQUENCE: H-Ser-Phe-Leu-Leu-Arg-Asn-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: SFLLRN

MOLECULAR FORMULA: C₃₄H₅₆N₁₀O₉

MOLECULAR WEIGHT: 748.88

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [141136-83-6]

SYNONYMS: Thrombin Receptor Activator Peptide 6, Thrombin Receptor (1-6) (human), PAR-1 (1-6) (human), Proteinase Activated Receptor 1 (1-6) (human), SFLLRN, Coagulation Factor II Receptor (1-6) (human)

RESEARCH AREA: Hematology

REFERENCES:
L.F.Brass et al., J. Biol. Chem., 269, 2943 (1994)
R.Kaufmann et al., NeuroReport, 9, 709 (1998)
B.A.Olson et al., Pharmacology, 58, 200 (1999)
H.Andersen et al., Proc. Natl. Acad. Sci. USA, 96, 11189 (1999)
R.Kaufmann et al., J. Neurooncol., 42, 131 (1999)
C.-C.Wu et al., Br. J. Pharmacol., 130, 1289 (2000)
H.Shankar et al., Blood, 104, 1335 (2004)
J.C.Resendiz et al., J. Thromb. Haemost., 5, 2484 (2007)
Scarborough, RM. et al. J. Biol. Chem. 267, 13146 (1992)
Ahmad, S. and PN. Walsh, Biochem. 44, 13858 (2005)
Buergler, M. et al. J. Thromb. Thrombolysis 19, 115 (2005)

SKU(s): PARP-018A, PARP-018B

KEYWORDS: