Description

This peptide based on the proteolytically-revealed tethered ligand sequence of the murine proteinase-activated receptor-4 (PAR-4) was shown to cause platelet aggregation with an EC50 value of about 15 µM. PAR-4 agonist peptide stimulates thromboxane production by human platelets with the maximal response to this agonist being approximately half of that observed after maximal thrombin stimulation.

SEQUENCE: H-Ala-Tyr-Pro-Gly-Lys-Phe-NH2 (trifluoroacetate salt)

ONE-LETTER SEQUENCE: AYPGKF-NH2

MOLECULAR FORMULA: C₃₄H₄₈N₈O₇

MOLECULAR WEIGHT: 680.8

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [352017-71-1]

SYNONYMS:

RESEARCH AREA: Hematology

REFERENCES:
T.R.Faruqi et al., J. Biol. Chem., 275, 19728 (2000)
M.D.Hollenberg and M.Saifeddine, Can. J. Physiol. Pharmacol., 79, 439 (2001)
R.A.Henriksen and V.K.Hanks, Arterioscler. Thromb. Vasc. Biol., 22, 861 (2002)
Sabri, A. et al. J. Biol. Chem. 278, 11714 (2003)
Ma, L. et al. Proc. Natl. Acad. Sci. USA 102, 216 (2005)

SKU(s): PARP-015A, PARP-015B

KEYWORDS: