Description

This peptide also known as INS is the 15-23 fragment of the insulin beta chain recognized by islet-associated T cells. It was used in diabetes studies to assay the IFN-beta and IL-17 production by diabetogenic CD4 or CD8 T cells. This peptide stains the INS-reactive CTL clone, but doesn?t stain the splenic CD8+ T cells from NOD or 8.3-TCR-transgenic NOD mice.

SEQUENCE: H-Leu-Tyr-Leu-Val-Cys-Gly-Glu-Arg-Gly-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: LYLVCGERG

MOLECULAR FORMULA: C₄₄H₇₂N₁₂O₁₃S₁

MOLECULAR WEIGHT: 1009.19

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER:

SYNONYMS:

RESEARCH AREA: Gastrointestinal

REFERENCES:
Hu, C. et al. J. Clin. Invest. 117, 3857 (2007)
Amrani, A. et al. Nature 406, 739 (2000)

SKU(s): PANP-006A, PANP-007

KEYWORDS: hormone