Description

This peptide is the fragment 6-38 of PACAP, which is a much more potent and selective inhibitor of PACAP-27-stimulated pituitary adenylate cyclase than PACAP (6-27). Ki values for the inhibition of the enzyme were 7 nM and 150 nM respectively.

SEQUENCE: H-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2 (trifluoroacetate salt)

ONE-LETTER SEQUENCE: FTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK-NH2

MOLECULAR FORMULA: C₁₈₂H₃₀₀N₅₆O₄₅S₁

MOLECULAR WEIGHT: 4024.8

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [143748-18-9]

SYNONYMS: Pituitary Adenylate Cyclase Activating Polypeptide-38 (6-38) (human, chicken, mouse, ovine, porcine, rat)

RESEARCH AREA: Hormonal

REFERENCES:
P. Robberecht et al., Mol. Pharmacol., 42, 347 (1992)
P. Robberecht et al., Eur. J. Biochem., 207, 239 (1992)
F. Ohno et al., Regul. Peptides, 126, 115 (2005)
P. Robberecht, P. Gourlet, P. De Neef, M-C. Woussen-Colle, M-C. Vandermeers-Piret,A. Vandermeers, and J. Christophe, Eur. J. Biochem., 207, 239 (1992) (Original)
A. Vandermeers, S. Vandenborre, X. Hou, P. De Neef, P. Robberecht, M-C. Vandermeers-Piret,and J. Christophe, Eur. J. Biochem., 208, 815 (1992) (Pharmacol.)

SKU(s): PACA-008A, PACA-008B

KEYWORDS: hormone