Description

PACAP-38 and its N-terminal fragment PACAP-27 are novel neuropeptides originally isolated from bovine hypothalamus. They are also found in humans and rats. Both PACAP-27 and PACAP-38, showing considerable homology with vasoactive intestinal polypeptide (VIP), can stimulate adenylate cyclase much more potently than VIP.

SEQUENCE: H-His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-NH2 (trifluoroacetate salt)

ONE-LETTER SEQUENCE: HSDGIFTDSYSRYRKQMAVKKYLAAVL-NH2

MOLECULAR FORMULA: C₁₄₂H₂₂₄N₄₀O₃₉S₁

MOLECULAR WEIGHT: 3147.65

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [127317-03-7]

SYNONYMS: Pituitary Adenylate Cyclase Activating Polypeptide-27 (human, mouse, ovine, porcine, rat), PACAP-27 (human, mouse, ovine, porcine, rat)

RESEARCH AREA: Hormonal

REFERENCES:
A. Miyata et al., BBRC, 164, 567 (1989)
A. Mirata et al., Regulatory Peptides, 26, 170 (1989)

SKU(s): PACA-004A, PACA-004B

KEYWORDS: hormone