Description

Carbetocin shows a prolonged effect due to an increased resistance to enzymatic cleavage. Carbetocin is highly effective in preventing post-partum hemorrhage after vaginal delivery.

SEQUENCE: Butyryl-Tyr(Me)-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (trifluoroacetate salt)
(Sulfide bond between Butyryl-4-yl and Cys)

ONE-LETTER SEQUENCE: Butyryl-Y(Me)-INCPLG-NH2

MOLECULAR FORMULA: C₄₅H₆₉N₁₁O₁₂S₁

MOLECULAR WEIGHT: 988.18

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [37025-55-1]

SYNONYMS: Pabal, Duratocin, Lonactene, Depotocin, Carbansin, Carbetoxin, Carbetocinum, CARBAOXYTOCIN, Carbetocin Acetate

RESEARCH AREA: Hormonal

REFERENCES:
T.Barth et al., Coll. Czech. Chem. Commun., 46, 2441 (1981)
N.Cort et al., Am. J. Vet. Res., 43, 1283 (1982)
V.Klenerova et al., J. Physiol. Pharmacol., 60, 57 (2009)
N.C.Peters and J.J.Duvekot, Obstet. Gynecol. Surv., 64, 129 (2009)
W.Rath, Eur. J. Obstet. Gynecol. Reprod. Biol., 147, 15 (2009)

SKU(s): OXYT-002A, OXYT-002B

KEYWORDS: thioether, peptide macrocycle