Description

Hypothalamic neuropeptide that regulates feeding behavior and significantly augments food intake in a dose-dependent manner when a bolus is administered intracerebroventricularly. Heavy Orexin A, human is isotopically labeled (U13C6,15N) at positions 3 (Leu) and 16 (Leu) is used in an LC-MS/MS method for measurement of Hcrt1 in CSF with automated sample preparation by solid-phase extraction (SPE).

SEQUENCE: Glp-Pro-Leu(U13C6,15N)-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu(U13C6,15N)-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 (Cys6 and Cys12/Cys7 and Cys14 Bridges) (trifluoroacetate salt)

ONE-LETTER SEQUENCE: Glp-PLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2 (Cys6 & Cys12/Cys7 & Cys14 Bridges)

MOLECULAR FORMULA:

MOLECULAR WEIGHT: 3575.2

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER:

SYNONYMS:

RESEARCH AREA: Obesity

REFERENCES:
Bårdsen, Kjetil, et al. Analytical Chemistry 91, no. 14 (2019): 9323-9329.
M.W. Schwartz, Nature Med., 4, 385 (1998)
T. Sakurai et al., Cell, 92, 573 (1998)

KEYWORDS: hormone