Description

Hypothalamic neuropeptide that regulates feeding behavior and significantly augments food intake in a dose-dependent manner when a bolus is administered intracerebroventricularly. After a 48-hour fast, hypothalamic prpro-orexin mRNA level is up-regulated 2.4. The discovery of orexins and their receptors may provide a novel molecular basis for understanding the role of the lateral hypothalamic areas in the regulation of energy homeostasis.

SEQUENCE: Glp-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 (trifluoroacetate salt)
(Cys6 and 12 bridge, Cys7 and 14 bridge)

ONE-LETTER SEQUENCE: Glp-PLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2 (C6&C12 bridge, C7&C14 bridge)

MOLECULAR FORMULA: C₁₅₂H₂₄₃N₄₇O₄₄S₄

MOLECULAR WEIGHT: 3561.16

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [205640-90-0]

SYNONYMS: Hypocretin-1 (human, mouse, rat), Orexin A, human, bovine, rat, mouse, Orexin A (human, mouse, rat)

RESEARCH AREA: Obesity

REFERENCES:
M.W. Schwartz, Nature Med., 4, 385 (1998)
T. Sakurai et al., Cell, 92, 573 (1998)

SKU(s): OREX-001A, OREX-001B

KEYWORDS: hormone