Description

This peptide was originally isolated from rat brain as an endogenous ligand for two orphan G protein-coupled receptors FM-3/GPR66 and FM-4/TGR-1, which have been identified as neuromedin U (NMU) receptors. hNMS-33 is specifically expressed in the suprachiasmatic nuclei (SCN) of the hypothalamus. It has been shown that NMS is implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions.

SEQUENCE: H-Ile-Leu-Gln-Arg-Gly-Ser-Gly-Thr-Ala-Ala-Val-Asp-Phe-Thr-Lys-Lys-Asp-His-Thr-Ala-Thr-Trp-Gly-Arg-Pro-Phe-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2 (trifluoroacetate salt)

ONE-LETTER SEQUENCE: ILQRGSGTAAVDFTKKDHTATWGRPFFLFRPRN-NH2

MOLECULAR FORMULA: C₁₇₃H₂₆₅N₅₃O₄₄

MOLECULAR WEIGHT: 3791.34

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [1138204-27-9]

SYNONYMS:

RESEARCH AREA: Obesity

REFERENCES:
K.Mori et al., EMBO J., 24, 325 (2005)

SKU(s): NEUP-007A, NEUP-007B

KEYWORDS: