Description

Afamelanotide, a synthetic analog of alpha-MSH which shows prolonged biological activity and is 26 times more active than alpha-MSH in the adenylate cyclase assay.

SEQUENCE: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2

ONE-LETTER SEQUENCE: Ac-SYS-Nle-EHfRWGKPV-NH2

MOLECULAR FORMULA: C₇₈H₁₁₁N₂₁O₁₉

MOLECULAR WEIGHT: 1646.87

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [75921-69-6]

SYNONYMS: melanotropins, Melanotan 1, NDP-MSH, Afamelanotide, CUV1647, [Nle4, DPhe7] a-MSH, amide

RESEARCH AREA: Hormonal

CATEGORY: Melanocyte Stimulating Hormones (MSH)

REFERENCES:
T.K.Sawyer et al., Proc. Natl. Acad. Sci. USA, 77, 5754 (1980)
M.E.Hadley et al., Science, 213, 1025 (1981)
K.R.Gehlsen et al., Pigment Cell Res., 5, 219 (1992)
S.O.Ugwu et al., Biopharm. Drug Dispos., 18, 259 (1997)
R.T.Dorr et al., Arch. Dermatol., 140, 827 (2004)
M.E.Hadley and R.T.Dorr, Peptides, 27, 921 (2006)

SKU(s): MSHS-003A, MSHS-003B, MSHS-003C

KEYWORDS: hormone