Description

Substrate that is hydrolyzed 60 times more rapidly by stromelysin 1 (MMP-3) (kcat/Km= 59400 M^-1s^-1) than by interstitial collagenase (MMP-1). However, it presents little discrimination between MMP-3, gelatinase A (MMP-2)(kcat/Km= 5400 M^-1s^-1), and gelatinase B (MMP-9)(kcat/Km= 55300 M^-1s^-1).

SEQUENCE: MCA-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(DNP)-NH2 (trifluoroacetate salt)

ONE-LETTER SEQUENCE: Mca-RPKPYA-Nva-WM-Lys(Dnp)-NH2

MOLECULAR FORMULA: C₇₉H₁₀₅N₁₉O₁₉S₁

MOLECULAR WEIGHT: 1656.89

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [158584-08-8]

SYNONYMS: Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH₂

RESEARCH AREA: Cancer

REFERENCES:
H. Nagase, et al., J. Biol. Chem., 269, 20952 (1994)

SKU(s): MMPS-024A, MMPS-024B, MMPS-024C

KEYWORDS: dye-labeled, FRET Substrate