Description

This peptide derived from the ligand binding site of the human gamma-interferon (IFN-gamma) receptor is an antagonist of human IFN-gamma. It inhibited human IFN-gamma-induced expression of HLR/DR antigen on Colo 205 cells with an approximate IC50 of 35 ?M. Immobilized peptide specifically bound recombinant human IFN-gamma. Tyrosine substitution at residue 121 allowed facile quantification and conjugation of the peptide.

SEQUENCE: H-Ala-Tyr-Cys(Acm)-Arg-Asp-Gly-Lys-Ile-Gly-Pro-Pro-Lys-Leu-Asp-Ile-Arg-Lys-Glu-Glu-Lys-Gln-Ile-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: AYC(Acm)RDGKIGPPKLDIRKEEKQI

MOLECULAR FORMULA: C₁₁₅H₁₉₄N₃₄O₃₄S₁

MOLECULAR WEIGHT: 2629.08

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [158040-83-6]

SYNONYMS:

RESEARCH AREA: Miscellaneous

REFERENCES:
G.F.Seelig et al., J. Biol. Chem., 270, 9241 (1995)

SKU(s): LYMK-002A, LYMK-002B

KEYWORDS: