Description

FK-13 is the core sequence of LL-37 and is resistant to proteolysis in bacteria. Removing the terminal phenylalanine results in inactivation making FKRIVQRIKDFLR minimal active sequence. FK-13 exhibits activity against HIV-1 (EC₅₀ 3.4 µM)

SEQUENCE: H-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: FKRIVQRIKDFLR

MOLECULAR FORMULA: C₈₀H₁₃₅N₂₅O₁₇

MOLECULAR WEIGHT: 1719.11

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [717919-68-1]

SYNONYMS: Cationic Antimicrobial Protein 18 (150-162) (human), hCAP18 (150-162), LL17 – 29, LL-37 (17-29)

RESEARCH AREA: Antimicrobial

REFERENCES:
A.Sol et al., RCS Adv., 5, 9361 (2015)
G.Wang et al., Antimicrob. Agents Chemother., 52, 3438 (2008)

SKU(s): LL37-006A, LL37-006B

KEYWORDS: