Description

LL-37 is an antimicrobial peptide with angiogenic activity. It corresponds to the C-terminal sequence (134-170) of the human cathelicidin antimicrobial protein hCAP18/LL-37 and is extracellularly released from hCAP18/LL-37 by proteolytic processing. hCAP18/LL-37 is an effector of the innate immune system and is expressed in leukocytes and epithelial cells where it is upregulated in association with inflammation and injury. An overexpression of hCAP18/LL-37 in a series of breast carcinomas could be demonstated. LL-37 has been suggested to stimulate epithelial cell proliferation partially through formyl peptide receptor-like 1 (FPRL1) since blocking the receptor with pertussis toxin decreased the proliferative effect of LL-37 by approximately 50 %.

SEQUENCE: H-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES

MOLECULAR FORMULA: C₂₀₅H₃₄₀N₆₀O₅₃

MOLECULAR WEIGHT: 4493.27

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [154947-66-7]

SYNONYMS: Antibacterial Protein LL-37 (human), LL37, CAMP

RESEARCH AREA: Antimicrobial

PRODUCT CITATIONS:
Fumakia, Miral D., and Emmanuel Abraham Ho. Molecular Pharmaceutics (2016).»
Chen, Yufei, Sidi Yang, and Emmanuel A. Ho. Chromatographia 77.23-24 (2014): 1713-1720.»
Srakaew, Nopparat, et al. Human Reproduction 29.4 (2014): 683-696.»
Choi, Ka-Yee G., Scott Napper, and Neeloffer Mookherjee. Immunology 143.1 (2014): 68-80.»
Mookherjee, Neeloffer. U.S. Patent Application No. 13/581,227 (2013).»
Madera, Laurence. Electronic Theses and Dissertations (ETDs) 2008+ (2012).»
Madera, Laurence, and Robert EW Hancock. Journal of Innate Immunity 4.5-6 (2012): 553-568.»
Walters, S. M., et al. Peptides 31.9 (2010): 1649-1653.»
Dixon, Douglas R., et al. Peptides 30.12 (2009): 2161-2167.»

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SKU(s): LL37-002A, LL37-002B, LL37-002C

KEYWORDS: