Description

Cetrorelix is a synthetic peptide gonadotropin-releasing hormone (GnRH) antagonist. The injectable generic formulation of cetrorelix is used in assisted reproduction to inhibit premature luteinizing hormone surges. In addition, cetrorelix has indications in hormone-sensitive cancers of the prostate and breast and certain benign gynaecological disorders such as endometriosis, uterine fibroids and endometrial thinning.intravenously. Cetrorelix blocks the effects of Gonadotropin Releasing Hormone (GnRH) and regulates the amount of luteinizing hormone (LH) released that triggers ovulation during the menstrual cycle. Some hormone therapies result in premature ovulation which causes eggs to be released before they are capable of being fertilized.

SEQUENCE: Ac-D-2-Nal-4-chloro-D-Phe-beta-(3-pyridyl)-D-Ala-Ser-Tyr-D-Cit-Leu-Arg-Pro-D-Ala-NH2 (acetate salt)

ONE-LETTER SEQUENCE: Ac-D-2-Nal-4-chloro-D-F-beta-(3-pyridyl)-D-ASY-D-Cit-LRPa-NH2

MOLECULAR FORMULA: C₇₀H₉₂Cl₁N₁₇O₁₄

MOLECULAR WEIGHT: 1431.06

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [120287-85-6]

SYNONYMS:

RESEARCH AREA: Hormonal

CATEGORY: LHRH (GnRH) Antagonists »

REFERENCES:
T.Reissmann et al., Hum. Reprod. Update, 6, 322 (2000)
G.Emons et al., Endocr. Relat. Cancer, 10, 291 (2003)
D.B.Shapiro and D.Mitchell-Leef, Minerva Ginecol., 55, 373 (2003)
C.Gründker et al., Eur. J. Endocrinol., 151, 141 (2004)

SKU(s): LHRH-022A, LHRH-022B

KEYWORDS: hormone