Description

This 20-residue peptide, a major pathogenic T-cell epitope (161?180), is present in the first homologous repeat of the interphotoreceptor retinoid binding protein peptide (IRBP). It has been shown to induce posterior uveitis (EAU).

SEQUENCE: H-Ser-Gly-Ile-Pro-Tyr-Ile-Ile-Ser-Tyr-Leu-His-Pro-Gly-Asn-Thr-Ile-Leu-His-Val-Asp-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: SGIPYIISYLHPGNTILHVD

MOLECULAR FORMULA: C₁₀₃H₁₅₇N₂₅O₂₉

MOLECULAR WEIGHT: 2209.5

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [211426-18-5]

SYNONYMS:

RESEARCH AREA: Immunomodulation

REFERENCES:
Sonoda, K. et al. J. Immunol. 171, 2652 (2003)
Read, RW. and SR. Barnum, ARVO Meeting Abstracts 43, 2281 (2002)
Silver, P. et al. Invest. Ophthal. Vis. Sci. 36, 946 (1995)
Karabekian, Z. et al. Invest. Ophthalmol. Vis. Sci. 46, 3769 (2005).

SKU(s): IRBP-002A, IRBP-002B

KEYWORDS: