Description

For exerting its anti-inflammatory and immunomodulatory activity, the peptide hormone thymulin, pEAKSQGGSN, requires the presence of Zn(II). Thymulin showed promising results in experimental models of lung diseases as well as potential as an analgesic peptide.

SEQUENCE: Pyr-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: Pyr-AKSQGGSN

MOLECULAR FORMULA: C₃₃H₅₄N₁₂O₁₅

MOLECULAR WEIGHT: 858.86

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [63958-90-7]

SYNONYMS:

RESEARCH AREA: Immunomodulation

REFERENCES:
J.F.Bach et al., Bull. Inst. Pasteur, 325 (1978)
T.L.K.Low and A.L.Goldstein, Springer Semin. Immunopathol., 2, 169 (1979)
J.J.E.Haddad et al., Biochem. Biophys. Res. Commun., 274, 500 (2000)
S.C.Land and F.Darakshan, Am. J. Physiol. Lung Cell. Mol. Physiol., 286, L473 (2004)
M.Dardenne et al., Ann. N. Y. Acad. Sci., 1088, 153 (2006)
T.Henriques-Coelho et al., Endocrinology, 149, 4367 (2008)
P.C.Reggiani et al., Ann. N. Y. Acad. Sci., 1153, 98 (2009)
H.Folch et al., Biol. Res., 43, 291 (2010)
M.Santos et al., Expert Opin. Ther. Targets, 14, 131 (2010)

SKU(s): IMMO-003A, IMMO-003B

KEYWORDS: