Description

This peptide is the fragment of Histone H3 (21-44) tri-methylated at Lys27 with an additional C-terminal Lys and biotinylation on the epsilon side chain of this Lys. Tri-methylation of Lys27 promotes Polycomb protein (Pc)-chromatin association and is associated with heterochromatin assembly and gene silencing.

SEQUENCE: H-Ala-Thr-Lys-Ala-Ala-Arg-Lys(Me3)-Ser-Ala-Pro-Ala-Thr-Gly-Gly-Val-Lys-Lys-Pro-His-Arg-Tyr-Arg-Pro-Gly-Lys(Biotin)-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: ATKAAR-K(Me3)-SAPATGGVKKPHRYRPG-K(Biotin)

MOLECULAR FORMULA:

MOLECULAR WEIGHT: 2902.4

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER:

SYNONYMS:

RESEARCH AREA: Miscellaneous

REFERENCES:
Zhang, X. et al. Nat Struct Mol Biol 14, 869 (2007)
Min, J. et al. Genes Dev 17, 1823 (2003)

SKU(s): HIST-058A, HIST-058B

KEYWORDS: