Description

This peptide activates the guanylate cyclase in the intestine and stimulates the production of cGMP that results in a secretory diarrhoea, thereby playing a role in regulating fluid and electrolyte absorption in intestines.

SEQUENCE: H-Pro-Asn-Thr-Cys-Glu-Ile-Cys-Ala-Tyr-Ala-Ala-Cys-Thr-Gly-Cys-OH (trifluoroacetate salt)
(Cys4 and 12 bridge, Cys7 and 15 bridge)

ONE-LETTER SEQUENCE: PNTCEICAYAACTGC (C4&C12 bridge, C7&C15 bridge)

MOLECULAR FORMULA: C₆₀H₉₀N₁₆O₂₂S₄

MOLECULAR WEIGHT: 1515.73

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [144940-98-7]

SYNONYMS:

RESEARCH AREA: Gastrointestinal

REFERENCES:
R.C. Wiegand et al., BBRC, 185, 812 (1992)

SKU(s): GUAN-002A, GUAN-002B

KEYWORDS: