GHK possesses a high affinity for copper(II) ions, with which it spontaneously forms a complex (GHK-Cu). This growth-modulating plasma tripeptide, when added at nanomolar concentrations to a wide group of cultured systems, produces a disparate set of responses ranging from the stimulation of growth and differentiation to outright toxicity. It may function by facilitating copper uptake into cells. GHK-Cu accelerates wound healing. The palmitoylated peptide is marketed as a cosmetic ingredient under the trade name Biopeptide CL. CAS Number (net): 49557-75-7.

SEQUENCE: H-Gly-His-Lys-OH (acetate salt)

ONE-LETTER SEQUENCE: GHK

MOLECULAR FORMULA: C₁₄H₂₄N₆O₄

MOLECULAR WEIGHT: 340.38

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [72957-37-0]

SYNONYMS: Prezatide, GHK

RESEARCH AREA: Miscellaneous

REFERENCES:
S.-J.Lau and B.Sarkar, Biochem. J., 199, 649 (1981)
J.-P.Laussac et al., Biochem. J., 209, 533 (1983)
D.Downey et al., Surg. Forum, 36, 573 (1985)
L.Pickart and S.Lovejoy, Meth. Enzymol., 147, 314 (1987)
F.-X.Maquart et al., FEBS Lett., 238, 343 (1988)

SKU(s): GRFF-008A

KEYWORDS: