Description

Oxyntomodulin is a potent inhibitor of gastric acid secretion and pancreatic enzyme secretion when infused iv. It was also proposed that intracerebroventricularly and into the hypothalamic paraventricular nucleus injected oxyntomodulin inhibits food intake in fasted and nonfasted animals potently and in a sustained manner.

SEQUENCE: H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-Lys-Arg-Asn-Arg-Asn-Asn-Ile-Ala-OH

ONE-LETTER SEQUENCE: HSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIA

MOLECULAR FORMULA: C₁₉₂H₂₉₅N₆₁O₆₀S₁

MOLECULAR WEIGHT: 4449.90

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [159002-68-3]

SYNONYMS: Glucagon-37 (human, mouse, rat), Preproglucagon (53-89) (human, mouse, rat), OXM (human, mouse, rat), Proglucagon (33-69) (human, mouse, rat)

RESEARCH AREA: Diabetes

REFERENCES:
C.L.Dakin et al., Endocrinology, 142, 4244 (2001)

SKU(s): GLUC-015A, GLUC-015B

KEYWORDS: hormone