Description

GLP-2 increases the stimulation of crypt cell proliferation and inhibition of enterocyte apoptosis, leading to hyperplasia of the small bowel villous epithelium. It also induces trophic effects in animal models of both small and large bowel injury such as experimental small bowel resection or chemically induced colitis. Besides stimulation of epithelial proliferation, GLP-2 acutely regulates gastric emptying and possesses rapid metabolic effects promoting the stimulation of intestinal hexose transport.

SEQUENCE: H-His-Ala-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Thr-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: HADGSFSDEMNTILDNLATRDFINWLIQTKITD

MOLECULAR FORMULA: C₁₆₆H₂₅₆N₄₄O₅₆S₁

MOLECULAR WEIGHT: 3796.19

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [195262-56-7]

SYNONYMS: Proglucagon (126-158) (rat), Preproglucagon (146-178) (rat), Glucagon-Like Peptide 2 (rat), GLP-2 (rat)

RESEARCH AREA: Diabetes

REFERENCES:

SKU(s): GLUC-012A, GLUC-012B

KEYWORDS: hormone