Description

The GLP-1 fragment is isolated from the lower small intestine and is presently regarded to be the most important incretin hormone. It shows a strong insulinotropic effect that is mediated by receptors expressed in the pancreatic beta-cells. It is proposed to be a novel therapeutic strategy for non-insulin-dependent (type 2) diabetes mellitus and associated neuropathy.

SEQUENCE: H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2

ONE-LETTER SEQUENCE: HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR-NH2

MOLECULAR FORMULA: C₁₄₉H₂₂₆N₄₀O₄₅

MOLECULAR WEIGHT: 3297.68

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [107444-51-9]

SYNONYMS: GLP-1 fragment, Proglucagon (78-107) amide (human, bovine, guinea pig, mouse, rat), Preproglucagon (98-127) amide (human, bovine, guinea pig, mouse, rat), Glucagon-Like Peptide 1 (7-36) amide (human, bovine, guinea pig, mouse, rat)

RESEARCH AREA: Diabetes

REFERENCES:
G. Bell et al., Nature, 304, 368 (1983)

SKU(s): GLUC-010A, GLUC-010B

KEYWORDS: hormone