Description

GLP, synthesized by posttranslational processing of proglucagon in the intestine and pancreas, plays an important role in metabolic homeostasis. It is capable of converting intestinal epithelial cells into insulin-producing cells, thus serving as a new putative therapeutic compound for the treatment of diabetes mellitus.

SEQUENCE: H-His-Asp-Glu-Phe-Glu-Arg-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly-OH (trifluoroacetate salt)

ONE-LETTER SEQUENCE: HDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG

MOLECULAR FORMULA: C₁₈₆H₂₇₅N₅₁O₅₉

MOLECULAR WEIGHT: 4169.6

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [87805-34-3]

SYNONYMS:

RESEARCH AREA: Diabetes

REFERENCES:
G.I. Bell et al., Nature, 304, 368 (1983)

SKU(s): GLUC-008A, GLUC-008B

KEYWORDS: hormone