Description

GIP fragment that presents potent insulinotropic activity in the isolated perfused rat pancreas, but greatly inhibits somatostatinotropic activity in the isolated perfused rat stomach. The site responsible for insulinotropic activity lies between 19 and 30 of GIP.

SEQUENCE: H-Tyr-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-Arg-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-NH2 (trifluoroacetate salt)

ONE-LETTER SEQUENCE: YAEGTFISDYSIAMDKIRQQDFVNWLLAQK-NH2

MOLECULAR FORMULA: C₁₆₂H₂₄₅N₄₁O₄₇S₁

MOLECULAR WEIGHT: 3551.04

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [134846-93-8]

SYNONYMS: Gastric Inhibitory Polypeptide (1-30) amide (porcine), Glucose-Dependent Insulinotropic Polypeptide (1-30) amide (porcine), GIP (1-30) amide (porcine)

RESEARCH AREA: Diabetes

REFERENCES:
W.J.Rossowski et al., Reg. Pep., 39, 9 (1992)

SKU(s): GIPS-002A, GIPS-002B

KEYWORDS: hormone