Description

A new member of the Glucagon superfamily that was originally isolated from the venom of the lizard, Heloderma Horridum. At low concentrations, it interacts with putative exendin receptors causing an increase in pancreatic acinar cAMP, while at higher concentrations it interacts with VIP receptors to stimulate an increase in cellular cAMP and amylase release.

SEQUENCE: H-His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 (trifluoroacetate salt)

ONE-LETTER SEQUENCE: HSDGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2

MOLECULAR FORMULA: C₁₈₄H₂₈₂N₅₀O₆₁S₁

MOLECULAR WEIGHT: 4202.63

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER: [130357-25-4]

SYNONYMS:

RESEARCH AREA: Diabetes

REFERENCES:
J. Eng et al., J. Biol. Chem., 267, 7402 (1992)

SKU(s): EXED-005A, EXED-005B

KEYWORDS: